Genetic Polymorphisms Associated with Liver Disease Progression in HIV/HCV-Coinfected Patients.
The pathogenic mechanisms of the accelerated progression of liver injury in HIV/HCV coinfection are incompletely understood. The progression of liver disease is variable between individuals having similar risk factors, suggesting that genetic background is an important contributor. The aim of this r...
| Publicado en: | AIDS Reviews Vol. 19; no. 1; pp. 3 - 16 |
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| Autores principales: | , , , |
| Formato: | Artículo |
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Publicidad Permanyer SLU
Jan-Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=121272701&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 121272701 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11396121 3PWJ jtl: AIDS Reviews issn: 11396121 maglogo: N pubinfo: dt: Jan-Mar2017 vid: 19 iid: 1 pid: 37650 pub: Publicidad Permanyer SLU artinfo: ui: 121272701 ppf: 3 ppct: 13 formats: fmt: @attributes: type: P size: 7.8MB tig: atl: Genetic Polymorphisms Associated with Liver Disease Progression in HIV/HCV-Coinfected Patients. aug: au: Medrano, Luz M. Jiménez-Sousa, María A. Fernández-Rodríguez, Amanda Resino, Salvador affil: Viral Infection and Immunity Unit, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. su: Liver diseases HIV infections Hepatitis C virus Single nucleotide polymorphisms Genetic polymorphisms Disease risk factors sug: subj: Liver diseases HIV infections Hepatitis C virus Single nucleotide polymorphisms Genetic polymorphisms Disease risk factors keyword: Cirrhosis Genetic polymorphism HCV/HIV coinfection Liver fibrosis Liver-related disease ab: The pathogenic mechanisms of the accelerated progression of liver injury in HIV/HCV coinfection are incompletely understood. The progression of liver disease is variable between individuals having similar risk factors, suggesting that genetic background is an important contributor. The aim of this review is to give a summary of all single nucleotide polymorphisms associated with the severity of liver disease in patients coinfected with HIV and HCV reported in the literature. Therefore, a systematic search for articles published was made, 17 of which were selected for this review. In summary, a large number of single nucleotide polymorphisms have been associated with the severity of liver disease in HIV/HCV-coinfected patients. These genes are involved in different biological processes, including seven that correspond to cytokine genes (IFNL3-4, CXCL9-11, IL15, TNF), two to receptor genes (IL7R, TLR8), and three are genes related to metabolism (PNPLA3, FTO, GSTM1). In addition, two combinations of polymorphisms (cirrhosis risk score and mitochondrial haplogroups) have also been related to severity of liver disease in HIV/HCV-coinfected patients. Although determinants other than genetics, such as environmental and viral factors, may be implicated in liver disease progression, information about genetic variation might be useful in clinical practice, allowing prioritization of patients with a genetic background that predispose to a worse evolution of HCV-related liver disease. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of AIDS Reviews is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: AIDS Reviews holder: Publicidad Permanyer SLU dt: @attributes: year: 2017 holdings: @attributes: islocal: N |
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