Ocular pyoderma gangrenosum: A systematic review.
Background: Pyoderma gangrenosum (PG) is a rare, ulcerative cutaneous disorder. Ophthalmic involvement in PG is atypical, but can have devastating consequences.Objective: We sought to characterize ocular PG to allow for earlier diagnosis and therapy. To our knowledge, this is the first systematic re...
| Publicado en: | Journal of the American Academy of Dermatology Vol. 76; no. 3; pp. 512 - 519 |
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| Autores principales: | , |
| Formato: | research systematic review Journal Article |
| Publicado: |
Elsevier B.V.
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121273248&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121273248 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01909622 1ZF jtl: Journal of the American Academy of Dermatology issn: 01909622 maglogo: N pubinfo: dt: Mar2017 vid: 76 iid: 3 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 121273248 121273248 NLM27836332 121273248 10.1016/j.jaad.2016.08.049 NLM27836332 121273248 ppf: 512 ppct: 7 formats: tig: atl: Ocular pyoderma gangrenosum: A systematic review. aug: au: Gupta, Angela S. Ortega-Loayza, Alex G. affil: School of Medicine, Virginia Commonwealth University, Richmond, Virginia sug: subj: Pyoderma Gangrenosum Therapy Pyoderma Gangrenosum Diagnosis Diagnosis, Eye Eye Diseases Therapy Comorbidity Diagnosis, Differential Eye Diseases Classification Pyoderma Gangrenosum Classification Human Systematic Review ab: Background: Pyoderma gangrenosum (PG) is a rare, ulcerative cutaneous disorder. Ophthalmic involvement in PG is atypical, but can have devastating consequences.Objective: We sought to characterize ocular PG to allow for earlier diagnosis and therapy. To our knowledge, this is the first systematic review summarizing this clinical variant.Methods: A systematic review was conducted using PubMed and Web of Science. Data were extracted and studies were qualitatively assessed and analyzed.Results: We identified all 34 cases of PG involving the eye and periorbital area, and categorized them into 4 different subtypes. Common presenting signs include ulceration, peripheral ulcerative keratitis, and decreased visual acuity. Although it is often difficult to biopsy ocular PG, histologic features are nonspecific. Combined therapy using corticosteroids and further surgical reconstruction as needed is the mainstay of treatment. Cases of the eye/orbit in particular should be treated aggressively, as these are more likely to relapse compared with cases of the periorbital area.Limitations: Use of case reports, paucity of ocular PG cases, and heterogeneity of studies are limitations.Conclusion: PG should be considered in the differential diagnosis of ulceration of ocular/periocular tissues. An aggressive, early, multimodal treatment strategy should be used to prevent relapse, especially in cases of the eye/orbit. pubtype: Academic Journal doctype: research systematic review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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