Identification of prognostic factors in patients with diffuse large B-cell lymphoma.
To identify prognostic factors for patients with diffuse large B-cell lymphoma (DLBCL), specifically those classified into conflicting subgroups by Hans' and Choi's classification algorithms. We retrospectively reviewed clinical and pathological data of 154 patients diagnosed with de novo DLBCL in t...
| Publicado en: | Indian Journal of Pathology & Microbiology Vol. 60; no. 1; pp. 87 - 92 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Jan-Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121285920&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121285920 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03774929 50DI jtl: Indian Journal of Pathology & Microbiology issn: 03774929 maglogo: N pubinfo: dt: Jan-Mar2017 vid: 60 iid: 1 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 121285920 121285920 NLM28195099 10.4103/0377-4929.200056 NLM28195099 121285920 ppf: 87 ppct: 5 formats: tig: atl: Identification of prognostic factors in patients with diffuse large B-cell lymphoma. aug: au: Fang Peng Liang Guo Wei-Kai Yao Yan Zheng Ye Liu Xiu-Mei Duan Yin-Ping Wang Peng, Fang Guo, Liang Yao, Wei-Kai Zheng, Yan Liu, Ye Duan, Xiu-Mei Wang, Yin-Ping affil: Department of Pathology, The First Hospital of Jilin University, Changchun, China sug: subj: Prognosis Lymphoma, B-Cell Pathology Lymphoma, B-Cell Diagnosis Aged, 80 and Over Neoplasm Grading Female Survival Analysis Adult Proteins Analysis Retrospective Design Peptide Hydrolases Analysis Lymphoma, B-Cell Mortality Male Aged Middle Age Scales Aged, 80 & over Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: To identify prognostic factors for patients with diffuse large B-cell lymphoma (DLBCL), specifically those classified into conflicting subgroups by Hans' and Choi's classification algorithms. We retrospectively reviewed clinical and pathological data of 154 patients diagnosed with de novo DLBCL in the First Hospital of Jilin University from January 2004 to September 2011. All cases were classified into subgroups based on Hans' and Choi's algorithms with immunohistochemical markers.Statistical Analysis Used: The correlation between various clinicopathological factors and 5-year survival rate, the correlation between those factors with the International Prognostic Index, the concordance between Hans' and Choi's approach was evaluated. The survival in different subtypes as classified by Hans' or Choi's approach was mapped.Results: The Eastern Cooperative Oncology Group (ECOG) performance score 2-5, positive Bcl-2 expression, negative CD10 expression or negative Bcl-6 expression significantly correlated with worse prognosis. The two algorithms showed good consistency (83% concordance, Kappa = 0.660, P < 0.001). By both classifications, the 5-year overall survival rate in germinal center B-cell-like subtype (GCB) lymphoma is significantly higher than that in the non-GCB subtype. There were 25 cases assigned to conflicting subtypes by the two approaches. Among these 25 cases, ECOG 2-5, positive Bcl-2 expression, negative CD10 expression, or negative Bcl-6 expression significantly correlated with worse prognosis.Conclusions: ECOG 2-5, positive Bcl-2 expression, negative CD10 expression, or negative Bcl-6 expression are independent markers for poor prognosis of DLBCL patients. There were 15% cases assigned to conflicting subgroups based on the two algorithms. For these cases, ECOG 2-5, positive Bcl-2 expression, negative CD10 expression, or negative Bcl-6 expression still significantly correlate with poor prognosis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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