MRI Patterns of brain injury and neurodevelopmental outcomes in neonates with severe anaemia at birth.
Aims: To define patterns of brain injury and associated neurodevelopmental outcomes in infants with severe neonatal anaemia.Methods: We studied 20 infants with severe anaemia at birth (haemoglobin<7g/dL). Clinical details were analysed for causes of anaemia and co-morbidities. All had early brain ma...
| Publicado en: | Early Human Development Vol. 105; pp. 17 - 23 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Feb2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121296450&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121296450 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03783782 3K7 jtl: Early Human Development issn: 03783782 maglogo: N pubinfo: dt: Feb2017 vid: 105 pid: 1004 pub: Elsevier B.V. artinfo: ui: 121296450 121296450 NLM28107673 121296450 10.1016/j.earlhumdev.2017.01.001 NLM28107673 121296450 ppf: 17 ppct: 6 formats: tig: atl: MRI Patterns of brain injury and neurodevelopmental outcomes in neonates with severe anaemia at birth. aug: au: Loureiro, Begoña Martinez-Biarge, Miriam Foti, Francesca Papadaki, Maria Cowan, Frances M Wusthoff, Courtney J affil: Departamento de Pediatría, Hospital Universitario Cruces, Barakaldo, Spain sug: subj: Anemia, Neonatal Brain Injuries Pregnancy Complications Developmental Disabilities Diagnosis Male Infant, Newborn Anemia, Neonatal Complications Infant Brain Injuries Complications Brain Magnetic Resonance Imaging Developmental Disabilities Etiology Female Infant, Newborn: birth-1 month Infant: 1-23 months Male Female ab: Aims: To define patterns of brain injury and associated neurodevelopmental outcomes in infants with severe neonatal anaemia.Methods: We studied 20 infants with severe anaemia at birth (haemoglobin<7g/dL). Clinical details were analysed for causes of anaemia and co-morbidities. All had early brain magnetic resonance imaging (MRI) scans, which were reviewed for injury pattern. Neurodevelopmental outcomes were assessed at a median age of 24months.Results: The aetiology of the anaemia was feto-maternal haemorrhage in 17 and antepartum haemorrhage in 3 infants. The predominant site of injury was the white matter, which was affected in all infants, with differing grades of severity and with cystic evolution in 45%. Only one infant showed an injury pattern typical of an acute severe hypoxic-ischaemic insult. Outcomes correlated closely to the severity of MRI findings. Cerebral palsy was seen only with the most severe neuroimaging patterns (n=6). Global developmental delay, learning or behavioural problems and seizures were common with moderate injury. Visual impairment occurred, particularly with posterior injury. Microcephaly developed in 45%.Interpretation: Severe neonatal anaemia at birth was associated with a white matter predominant pattern of injury, the severity of which was related to neurodevelopmental outcomes. Early MRI and long-term follow-up are advisable following severe neonatal anaemia. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|