Establishing Blend Uniformity Acceptance Criteria for Oral Solid-Dosage Forms.
With the current technologies for powder blend sampling, blend segregation during sampling (sampling bias) especially for granular blends will unavoidably occur, resulting in deviated (biased) blend assay results. This article introduces the concepts of pooled variance and the central limit theorem,...
| Publicado en: | Pharmaceutical Technology Vol. 41; no. 2; pp. 42 - 50 |
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| Formato: | Journal Article |
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MJH Life Sciences
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121309364&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121309364 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15432521 4FK jtl: Pharmaceutical Technology issn: 15432521 maglogo: N pubinfo: dt: Feb2017 vid: 41 iid: 2 pid: 54670 pub: MJH Life Sciences place: Cranbury, New Jersey artinfo: ui: 121309364 121309364 ppf: 42 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Establishing Blend Uniformity Acceptance Criteria for Oral Solid-Dosage Forms. aug: au: Cholayudth, Pramote affil: Founder and manager of PM Consult sug: ab: With the current technologies for powder blend sampling, blend segregation during sampling (sampling bias) especially for granular blends will unavoidably occur, resulting in deviated (biased) blend assay results. This article introduces the concepts of pooled variance and the central limit theorem, which are intended for establishing acceptance criteria for blend uniformity data of granular powder blends when a significant degree of sampling bias is involved. pubtype: Trade Publication doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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