Asymmetric Copper Hydride-Catalyzed Markovnikov Hydrosilylation of Vinylarenes and Vinyl Heterocycles.

We report a highly enantioselective CuH-catalyzed Markovnikov hydrosilylation of vinylarenes and vinyl heterocycles. This method has a broad scope and enables both the synthesis of isolable silanes and the conversion of crude products to chiral alcohols. Density functional theory calculations suppor...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 139; no. 6; pp. 2192 - 2196
Main Authors:	Gribble, Jr., Michael W., Pirnot, Michael T., Bandar, Jeffrey S., Liu, Richard Y., Buchwald, Stephen L.
Format:	Article
Published:	American Chemical Society 2/15/2017
Subjects:	Copper hydride Markovnikov's rule Hydrosilylation Aromatic compound derivatives Vinylation Asymmetric synthesis Enantioselective catalysis Density functional theory
Online Access:	View this record in EBSCOhost