Urease inhibition potential of Di-naphthodiospyrol from Diospyros lotus roots.
The dimeric napthoquione 5,8,4′-trihydroxy-1′-methoxy-6, 6′-dimethyl-7,3′-binaphtyl-1,4,5′,8′-tetraone (1) was isolated from the chloroform fraction ofDiospyros lotusextract.Compound1was screened for its inhibitory effects against four enzymes: urease, phosphodiesterase-I, carbonic anhydrase-II andα...
| Publicado en: | Natural Product Research Vol. 31; no. 10; pp. 1214 - 1219 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121333085&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121333085 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: 2017 vid: 31 iid: 10 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 121333085 10.1080/14786419.2016.1226832 121333085 ppf: 1214 ppct: 5 formats: tig: atl: Urease inhibition potential of Di-naphthodiospyrol from Diospyros lotus roots. aug: au: Rauf, Abdur Uddin, Ghias Raza, Muslam Patel, Seema Bawazeer, Saud Ben Hadda, Taibi Jehan, Noor Mabkhot, Yahia Nasser Khan, Ajmal Mubarak, Mohammad S. affil: Department of Geology, University of Swabi, Anbar, Pakistan sug: ab: The dimeric napthoquione 5,8,4′-trihydroxy-1′-methoxy-6, 6′-dimethyl-7,3′-binaphtyl-1,4,5′,8′-tetraone (1) was isolated from the chloroform fraction ofDiospyros lotusextract.Compound1was screened for its inhibitory effects against four enzymes: urease, phosphodiesterase-I, carbonic anhydrase-II andα-chymotrypsin, and showed selective activity against urease enzyme with an IC50value of 254.1 ± 3.82 μM as compared to the standard thiourea (IC50 = 21 ± 0.11 μM). Furthermore,in silicodocking study was carried out to explain the molecular mechanism of compound1against the target receptor. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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