Effect of Vonoprazan, a Potassium-Competitive Acid Blocker, on the 13C-Urea Breath Test in Helicobacter pylori-Positive Patients.
Background and Aim: Vonoprazan (VPZ) is a new oral potassium-competitive acid blocker that has recently become available. The aim of this study was to investigate the effects of VPZ on the urease activity of H. pylori as measured by the 13C-urea breath test (13C-UBT).Patients and Methods: A total of...
| Publicado en: | Digestive Diseases & Sciences Vol. 62; no. 3; pp. 739 - 746 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121387070&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121387070 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01632116 1VP jtl: Digestive Diseases & Sciences issn: 01632116 maglogo: N pubinfo: dt: Mar2017 vid: 62 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121387070 121387070 143998112 NLM28083842 121387070 10.1007/s10620-016-4439-0 NLM28083842 121387070 ppf: 739 ppct: 7 formats: tig: atl: Effect of Vonoprazan, a Potassium-Competitive Acid Blocker, on the 13C-Urea Breath Test in Helicobacter pylori-Positive Patients. aug: au: Takimoto, Mayu Tomita, Toshihiko Yamasaki, Takahisa Fukui, Shota Taki, Masato Okugawa, Takuya Kondo, Takashi Kono, Tomoaki Tozawa, Katsuyuki Arai, Eitatsu Ohda, Yoshio Oshima, Tadayuki Fukui, Hirokazu Watari, Jiro Miwa, Hiroto affil: Division of Gastroenterology, Department of Internal Medicine , Hyogo College of Medicine , 1-1, Mukogawa-cho Nishinomiya 663-8501 Japan sug: subj: Helicobacter Infections Drug Therapy Helicobacter Infections Diagnosis Heterocyclic Compounds Adverse Effects Lansoprazole Administration and Dosage Sulfonamides Administration and Dosage Helicobacter Pylori Helicobacter Pylori Drug Effects Sulfonamides Adverse Effects Heterocyclic Compounds Administration and Dosage Lansoprazole Adverse Effects Helicobacter Infections Microbiology Drug Monitoring Methods Aged Proton Pump Inhibitors Administration and Dosage Proton Pump Inhibitors Adverse Effects Female Urease Metabolism Adult Middle Age Breath Tests Methods Male Human Treatment Outcomes Validation Studies Comparative Studies Evaluation Research Multicenter Studies Randomized Controlled Trials Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background and Aim: Vonoprazan (VPZ) is a new oral potassium-competitive acid blocker that has recently become available. The aim of this study was to investigate the effects of VPZ on the urease activity of H. pylori as measured by the 13C-urea breath test (13C-UBT).Patients and Methods: A total of 60 patients (26 men, 34 women; mean age 53.2 ± 13.6 years) who were diagnosed as H. pylori-positive were recruited. The patients were randomly allocated to three treatment groups: lansoprazole (LPZ) 30 mg (n = 20), VPZ 20 mg (n = 20) once daily for 3 weeks, or the control group (n = 20). The 13C-UBT was carried out at baseline and after 3 weeks of treatment, and the baseline and after treatment results then compared. Δ13C‰ ≥ 2.5‰ was considered H. pylori-positive.Results: Four patients failed to complete the medication and were omitted from the analysis; data from the LPZ group (n = 18), VPZ group (n = 18), and control group (n = 20) were analyzed. The control group showed no significant change in 13C-UBT data between baseline and the completion of 3-week treatment (baseline: 26.6 ± 23.0‰, completion: 21.1 ± 13.1‰). The 13C-UBT data at week 3 were significantly decreased in both the VPZ group (baseline: 32.8 ± 22.7‰, completion: 7.6 ± 9.2‰, p = 0.0002) and the LPZ group (baseline: 41.8 ± 33.4‰; completion: 9.6 ± 8.8‰, p = 0.0006) compared to baseline.Conclusions: VPZ treatment reduced the value of UBT, warning that UBT for patients with VPZ treatment should be evaluated carefully. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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