Liver volume is a prognostic indicator for clinical outcome of patients with alcoholic hepatitis.
Purpose: To evaluate the prognostic value of abdominal computed tomography (CT) in patients with alcoholic hepatitis (AH). Methods: This ancillary study was based on data collected during a previous randomized controlled trial in patients with AH. Clinical response was defined as the improvement of...
| Publicado en: | Abdominal Radiology Vol. 42; no. 2; pp. 460 - 468 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121485316&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121485316 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Feb2017 vid: 42 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121485316 143953847 10.1007/s00261-016-0892-7 121485316 ppf: 460 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Liver volume is a prognostic indicator for clinical outcome of patients with alcoholic hepatitis. aug: au: Breguet, Romain Ronot, Maxime Goossens, Nicolas Hansen, Catrina Giostra, Emiliano Majno, Pietro Becker, Christoph Spahr, Laurent Terraz, Sylvain sug: ab: Purpose: To evaluate the prognostic value of abdominal computed tomography (CT) in patients with alcoholic hepatitis (AH). Methods: This ancillary study was based on data collected during a previous randomized controlled trial in patients with AH. Clinical response was defined as the improvement of the baseline MELD score ≥3 points at 3 months. All patients underwent contrast-enhanced CT of the abdomen. The following parameters were measured: (1) liver density, spleen density, and liver-to-spleen density ratio; (2) liver-to-body weight (LBW) ratio; and (3) subcutaneous fat, visceral fat, and muscular content. Improvers and non-improvers were compared with univariate, multivariate, and ROC analyses. Results were compared with a validation cohort of patients. Results: Fifty-eight patients (mean age, 56 years) were analyzed, including 34 (59 %) improvers. On multivariate analysis, LBW ratio (OR = 3.73; 95 % CI, 1.65-8.46; p = 0.002) and subcutaneous fat (OR = 1.01; 95 % CI, 1.00-1.02; p = 0.022) were associated with clinical response, with AUROC curves of 0.78 ± 0.06 ( p < 0.001) and 0.66 ± 0.07 ( p = 0.043), respectively. LBW ≥2.4 % predicted response with 88 % sensitivity and 63 % specificity. In the validation cohort ( n = 42, 64 % improvers), the same cut-off value predicted response with 93 % sensitivity and 60 % specificity. Conclusions: In patients suffering from AH, the liver volume appears to be a major positive prognostic factor. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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