Structural cerebellar correlates of cognitive and motor dysfunctions in cerebellar degeneration.
See King et al. (doi:10.1093/aww348) for a scientific commentary on this article.Detailed mapping of clinical dysfunctions to the cerebellar lobules in disease populations is necessary to establish the functional significance of lobules implicated in cognitive and motor functions in normal subjects....
| Publicado en: | Brain: A Journal of Neurology Vol. 140; no. 3; pp. 707 - 721 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121490870&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121490870 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00068950 2RY jtl: Brain: A Journal of Neurology issn: 00068950 maglogo: N pubinfo: dt: Mar2017 vid: 140 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 121490870 121490870 NLM28043955 121490870 10.1093/brain/aww327 NLM28043955 121490870 ppf: 707 ppct: 14 formats: tig: atl: Structural cerebellar correlates of cognitive and motor dysfunctions in cerebellar degeneration. aug: au: Kansal, Kalyani Zhen Yang Fishman, Ann M. Sair, Haris I. Ying, Sarah H. Jedynak, Bruno M. Prince, Jerry L. Onyike, Chiadi U. Yang, Zhen affil: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA sug: subj: Cognition Disorders Etiology Cerebellar Diseases Complications Cerebellum Pathology Severity of Illness Indices Middle Age Aged Cognition Disorders Cross Sectional Studies Female Magnetic Resonance Imaging Image Processing, Computer Assisted Nonparametric Statistics Neuropsychological Tests Adult Cerebellum Case Control Studies Male Statistics Cerebellar Diseases Cerebellum Physiopathology Funding Source Human Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Female Male ab: See King et al. (doi:10.1093/aww348) for a scientific commentary on this article.Detailed mapping of clinical dysfunctions to the cerebellar lobules in disease populations is necessary to establish the functional significance of lobules implicated in cognitive and motor functions in normal subjects. This study constitutes the first quantitative examination of the lobular correlates of a broad range of cognitive and motor phenomena in cerebellar disease. We analysed cross-sectional data from 72 cases with cerebellar disease and 36 controls without cerebellar disease. Cerebellar lobule volumes were derived from a graph-cut based segmentation algorithm. Sparse partial least squares, a variable selection approach, was used to identify lobules associated with motor function, language, executive function, memory, verbal learning, perceptual organization and visuomotor coordination. Motor dysfunctions were chiefly associated with the anterior lobe and posterior lobule HVI. Confrontation naming, noun fluency, recognition, and perceptual organization did not have cerebellar associations. Verb and phonemic fluency, working memory, cognitive flexibility, immediate and delayed recall, verbal learning, and visuomotor coordination were variably associated with HVI, Crus I, Crus II, HVII B and/or HIX. Immediate and delayed recall also showed associations with the anterior lobe. These findings provide preliminary anatomical evidence for a functional topography of the cerebellum first defined in task-based functional magnetic resonance imaging studies of normal subjects and support the hypotheses that (i) cerebellar efferents target frontal lobe neurons involved in forming action representations and new search strategies; (ii) there is greater involvement of the cerebellum when immediate recall tasks involve more complex verbal stimuli (e.g. longer words versus digits); and (iii) it is involved in spontaneous retrieval of long-term memory. More generally, they provide an anatomical background for studies that seek the mechanisms by which cognitive and motor dysfunctions arise from cerebellar degeneration. Beyond replicating these findings, future research should employ experimental tasks to probe the integrity of specific functions in cerebellar disease, and new imaging methods to quantitatively map atrophy across the cerebellum. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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