Differentiation of prostate cancer lesions with high and with low Gleason score by diffusion-weighted MRI.
Objectives: To differentiate prostate cancer lesions with high and with low Gleason score by diffusion-weighted-MRI (DW-MRI).Methods: This prospective study was approved by the responsible ethics committee. DW-MRI of 84 consenting prostate and/or bladder cancer patients scheduled for radical prostat...
| Publicado en: | European Radiology Vol. 27; no. 4; pp. 1547 - 1556 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121519085&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121519085 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2017 vid: 27 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121519085 121519085 NLM27300199 121519085 10.1007/s00330-016-4449-5 NLM27300199 121519085 ppf: 1547 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Differentiation of prostate cancer lesions with high and with low Gleason score by diffusion-weighted MRI. aug: au: Barbieri, Sebastiano Brönnimann, Michael Boxler, Silvan Vermathen, Peter Thoeny, Harriet Thoeny, Harriet C affil: Institute of Diagnostic, Pediatric, and Interventional Radiology , Inselspital University Hospital , Inselspital, Freiburgstrasse 10 CH-3010 Bern Switzerland sug: subj: Magnetic Resonance Imaging Methods Prostatic Neoplasms Pathology Prostatic Neoplasms Prostate Pathology Prostatectomy Prostate Image Interpretation, Computer Assisted Methods Prostatic Neoplasms Surgery Neoplasm Grading Prospective Studies Adult Male Aged Diagnosis, Differential Middle Age Aged, 80 and Over Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Aged, 80 & over Male ab: Objectives: To differentiate prostate cancer lesions with high and with low Gleason score by diffusion-weighted-MRI (DW-MRI).Methods: This prospective study was approved by the responsible ethics committee. DW-MRI of 84 consenting prostate and/or bladder cancer patients scheduled for radical prostatectomy were acquired and used to compute apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM: the pure diffusion coefficient D t, the pseudo-diffusion fraction F p and the pseudo-diffusion coefficient D p), and high b value (as acquired and Hessian filtered) parameters within the index lesion. These parameters (separately and combined in a logistic regression model) were used to differentiate lesions depending on whether whole-prostate histopathological analysis after prostatectomy determined a high (≥7) or low (6) Gleason score.Results: Mean ADC and D t differed significantly (p of independent two-sample t test < 0.01) between high- and low-grade lesions. The highest classification accuracy was achieved by the mean ADC (AUC 0.74) and D t (AUC 0.70). A logistic regression model based on mean ADC, mean F p and mean high b value image led to an AUC of 0.74 following leave-one-out cross-validation.Conclusions: Classification by IVIM parameters was not superior to classification by ADC. DW-MRI parameters correlated with Gleason score but did not provide sufficient information to classify individual patients.Key Points: • Mean ADC and diffusion coefficient differ between high- and low-grade prostatic lesions. • Accuracy of trivariate logistic regression is not superior to using ADC alone. • DW-MRI is not a valid substitute for biopsies in clinical routine yet. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|