Lung perfusion characteristics in pulmonary arterial hypertension (PAH) and peripheral forms of chronic thromboembolic pulmonary hypertension (pCTEPH): Dual-energy CT experience in 31 patients.
Purpose: To compare lung perfusion in PAH and pCTEPH on dual-energy CT (DECT) examinations.Materials and Methods: Thirty-one patients with PAH (group 1; n = 19) and pCTEPH (group 2; n = 12) underwent a dual-energy chest CTA with reconstruction of diagnostic and perfusion images. Perfusion alteration...
| Publicado en: | European Radiology Vol. 27; no. 4; pp. 1631 - 1640 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121519111&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121519111 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2017 vid: 27 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121519111 121519111 NLM27480438 10.1007/s00330-016-4500-6 NLM27480438 121519111 ppf: 1631 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Lung perfusion characteristics in pulmonary arterial hypertension (PAH) and peripheral forms of chronic thromboembolic pulmonary hypertension (pCTEPH): Dual-energy CT experience in 31 patients. aug: au: Giordano, Jessica Khung, Suonita Duhamel, Alain Hossein-Foucher, Claude Bellèvre, Dimitri Lamblin, Nicolas Remy, Jacques Remy-Jardin, Martine affil: Department of Thoracic Imaging , Hospital Calmette (EA 2694) , CHRU et Université de Lille 2 Nord de France 59000 Lille France sug: subj: Hypertension, Pulmonary Pulmonary Embolism Pulmonary Embolism Complications Male Adult Young Adult Tomography, X-Ray Computed Methods Aged, 80 and Over Middle Age Chronic Disease Hypertension, Pulmonary Etiology Female Diagnosis, Differential Perfusion Imaging Methods Angiography Methods Aged Adult: 19-44 years Aged, 80 & over Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: To compare lung perfusion in PAH and pCTEPH on dual-energy CT (DECT) examinations.Materials and Methods: Thirty-one patients with PAH (group 1; n = 19) and pCTEPH (group 2; n = 12) underwent a dual-energy chest CTA with reconstruction of diagnostic and perfusion images. Perfusion alterations were analysed at a segmental level. V/Q scintigraphy was available in 22 patients (group 1: 13/19; group 2: 9/12).Results: CT perfusion was abnormal in 52.6 % of group 1 patients and in 100 % of group 2 patients (p = 0.0051). The patterns of perfusion alteration significantly differed between the two groups (p < 0.0001): (1) in group 1, 96.6 % of segments with abnormal perfusion showed patchy defects; (2) in group 2, the most frequent abnormalities consisted of patchy (58.5 %) and PE-type (37.5 %) defects. Paired comparison of CT perfusion and scintigraphy showed concordant findings in 76.9 % of group 1 (10/13) and 100 % of group 2 (9/9) patients, with a predominant or an exclusive patchy pattern in group 1 and a mixed pattern of abnormalities in group 2.Conclusion: Lung perfusion alterations at DECT are less frequent and more homogeneous in PAH than in pCTEPH, with a high level of concordant findings with V/Q scintigraphy.Key Points: • Depiction of chronic pulmonary embolism exclusively located on peripheral arteries is difficult. • The main differential diagnosis of pCTEPH is PAH. • The pattern of DECT perfusion changes can help differentiate PAH and pCETPH. • In PAH, almost all segments with abnormal perfusion showed patchy defects. • In pCTEPH, patchy and PE-type defects were the most frequent abnormalities. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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