Primary central nervous system lymphoma and atypical glioblastoma: differentiation using the initial area under the curve derived from dynamic contrast-enhanced MR and the apparent diffusion coefficient.
Objectives: To evaluate the ability of the initial area under the curve (IAUC) derived from dynamic contrast-enhanced MR imaging (DCE-MRI) and apparent diffusion coefficient (ADC) in differentiating between primary central nervous system lymphoma (PCNSL) and atypical glioblastoma (GBM).Methods: We r...
| Publicado en: | European Radiology Vol. 27; no. 4; pp. 1344 - 1352 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121519125&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121519125 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2017 vid: 27 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121519125 121519125 NLM27436023 10.1007/s00330-016-4484-2 NLM27436023 121519125 ppf: 1344 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Primary central nervous system lymphoma and atypical glioblastoma: differentiation using the initial area under the curve derived from dynamic contrast-enhanced MR and the apparent diffusion coefficient. aug: au: Choi, Yoon Lee, Ho-Joon Ahn, Sung Chang, Jong Kang, Seok-Gu Kim, Eui Kim, Se Lee, Seung-Koo Choi, Yoon Seong Ahn, Sung Soo Chang, Jong Hee Kim, Eui Hyun Kim, Se Hoon affil: Department of Radiology and Research Institute of Radiological Science , Yonsei University College of Medicine , 50-1 Yonsei-ro Seodaemun-gu 03722 Korea sug: subj: Image Enhancement Methods Contrast Media Glioma Lymphoma Central Nervous System Neoplasms Magnetic Resonance Imaging Methods Aged Glioma Pathology Retrospective Design Female Lymphoma Pathology Central Nervous System Neoplasms Pathology Sensitivity and Specificity Brain Neoplasms Male Reproducibility of Results Middle Age Diagnosis, Differential Pharmacokinetics Brain Neoplasms Pathology Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: To evaluate the ability of the initial area under the curve (IAUC) derived from dynamic contrast-enhanced MR imaging (DCE-MRI) and apparent diffusion coefficient (ADC) in differentiating between primary central nervous system lymphoma (PCNSL) and atypical glioblastoma (GBM).Methods: We retrospectively identified 19 patients with atypical GBM (less than 13 % necrosis of the enhancing tumour), and 23 patients with PCNSL. The histogram parameters of IAUC at 30, 60, 90 s (IAUC30, IAUC60, and IAUC90), and ADC were compared between PCNSL and GBM. The diagnostic performances and added values of the IAUC and ADC for differentiating between PCNSL and GBM were evaluated. Interobserver agreement was assessed via intraclass correlation coefficient (ICC).Results: The IAUC and ADC parameters were higher in GBM than in PCNSL. The 90th percentile (p90) of IAUC30 and 10th percentile (p10) of ADC showed the best diagnostic performance. Adding p90 of IAUC30 to p10 of ADC improved the differentiation between PCNSL and GBM (area under the ROC curve [AUC] = 0.886), compared to IAUC30 or ADC alone (AUC = 0.789 and 0.744; P < 0.05 for all). The ICC was 0.96 for p90 of IAUC30.Conclusions: The IAUC may be a useful parameter together with ADC for differentiating between PCNSL and atypical GBM.Key Points: • High reproducibility is essential for practical implementation of advanced MRI parameters. • IAUC and ADC are highly reproducible parameters. • IAUC values were higher in atypical GBM than in PCNSL. • Adding IAUC to ADC improved the differentiation between PCNSL and GBM. • IAUC with ADC are useful for differentiating PCNSL from GBM. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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