Radiological and clinical outcomes of novel Ti/PEEK combined spinal fusion cages: a systematic review and preclinical evaluation.
Purpose: The primary objective of this paper was to provide a systematic review of the available clinical studies of Ti/PEEK combined cages in spinal interbody fusion surgeries, focusing on their radiological and clinical outcomes. A secondary aim was to provide a review and evaluation of the in vit...
| Publicado en: | European Spine Journal Vol. 26; no. 3; pp. 593 - 606 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121519173&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121519173 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09406719 NPI jtl: European Spine Journal issn: 09406719 maglogo: N pubinfo: dt: Mar2017 vid: 26 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121519173 121519173 NLM26671514 121519173 10.1007/s00586-015-4353-8 NLM26671514 121519173 ppf: 593 ppct: 13 formats: tig: atl: Radiological and clinical outcomes of novel Ti/PEEK combined spinal fusion cages: a systematic review and preclinical evaluation. aug: au: Assem, Yusuf Mobbs, Ralph Pelletier, Matthew Phan, Kevin Walsh, William Mobbs, Ralph J Pelletier, Matthew H Walsh, William R affil: Surgical and Orthopaedic Research Laboratory, Prince of Wales Clinical School , UNSW , Sydney Australia sug: subj: Ketones Titanium Spinal Fusion Equipment and Supplies Prostheses and Implants Polyethylene Glycols Prosthesis Design Human Biocompatible Materials Systematic Review ab: Purpose: The primary objective of this paper was to provide a systematic review of the available clinical studies of Ti/PEEK combined cages in spinal interbody fusion surgeries, focusing on their radiological and clinical outcomes. A secondary aim was to provide a review and evaluation of the in vitro and preclinical studies reported on Ti/PEEK-coated implants.Methods: A systematic search of the literature was performed in March 2015 via three databases: Medline, Embase and Cochrane library. The following key search terms were combined with synonyms to identify relevant articles: "spinal fusion," "PEEK," "titanium" and "cage."Results: The novelty of this intervention translates into a paucity of clinical trials, albeit the results of the seven clinical studies that met the criteria for inclusion are promising. All studies reported rate of fusion as a primary outcome. Two studies reported slightly improved fusion in the experimental Ti/PEEK combination cohort, one study identical fusion (91.7 %) and three studies excellent fusion (96, 100 and 94 %) in the Ti/PEEK cohort, although no differences reached statistical significance.Conclusions: Clinical studies at this early stage demonstrate that Ti/PEEK implants are safe and efficacious, exhibiting similar fusion rates and clinical outcomes compared to the current standard PEEK. There is clinical evidence substantiating the improved radiographic fusion of Ti/PEEK, albeit the differences were not significant. This field is promising, gaining substantial popularity, and further clinical trials are needed in the future to establish Ti/PEEK cages as a mainstay of clinical practice. pubtype: Academic Journal doctype: pictorial research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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