Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness.
Purpose: Creatine (Cr) is a major metabolite in the bioenergetic system. Measurement of Cr using conventional MR spectroscopy (MRS) suffers from low spatial resolution and relatively long acquisition times. Creatine chemical exchange saturation transfer (CrCEST) magnetic resonance imaging (MRI) is a...
| Publicado en: | Molecular Imaging & Biology Vol. 19; no. 2; pp. 225 - 233 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121548616&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121548616 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Apr2017 vid: 19 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121548616 121548616 143910202 NLM27541025 121548616 10.1007/s11307-016-0995-0 NLM27541025 121548616 ppf: 225 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness. aug: au: Cai, Kejia Tain, Rong-Wen Zhou, Xiaohong Damen, Frederick Scotti, Alessandro Hariharan, Hari Poptani, Harish Reddy, Ravinder Zhou, Xiaohong Joe Damen, Frederick C Scotti, Alessandro M affil: Department of Radiology and the Center for MR Research, College of Medicine , University of Illinois at Chicago , Chicago USA sug: subj: Magnetic Resonance Imaging Methods Creatine Glioma Pathology Cell Differentiation Brain Neoplasms Pathology Image Processing, Computer Assisted Animal Studies Neoplasm Invasiveness Signal Processing, Computer Assisted Rats Models, Biological Funding Source ab: Purpose: Creatine (Cr) is a major metabolite in the bioenergetic system. Measurement of Cr using conventional MR spectroscopy (MRS) suffers from low spatial resolution and relatively long acquisition times. Creatine chemical exchange saturation transfer (CrCEST) magnetic resonance imaging (MRI) is an emerging molecular imaging method for tissue Cr measurements. Our previous study showed that the CrCEST contrast, obtained through multicomponent Z-spectral fitting, was lower in tumors compared to normal brain, which further reduced with tumor progression. The current study was aimed to investigate if CrCEST MRI can also be useful for differentiating gliomas with different degrees of aggressiveness.Procedures: Intracranial 9L gliosarcoma and F98 glioma bearing rats with matched tumor size were scanned with a 9.4 T MRI scanner at two time points. CEST Z-spectra were collected using a customized sequence with a frequency-selective rectangular saturation pulse (B1 = 50 Hz, duration = 3 s) followed by a single-shot readout. Z spectral data were fitted pixel-wise with five Lorentzian functions, and maps of CrCEST peak amplitude, linewidth, and integral were produced. For comparison, single-voxel proton MR spectroscopy (1H-MRS) was performed to quantify and compare the total Cr concentration in the tumor.Results: CrCEST contrasts decreased with tumor progression from weeks 3 to 4 in both 9L and F98 phenotypes. More importantly, F98 tumors had significantly lower CrCEST integral compared to 9L tumors. On the other hand, integrals of other Z-spectral components were unable to differentiate both tumor progression and phenotype with limited sample size.Conclusions: Given that F98 is a more aggressive tumor than 9L, this study suggests that CrCEST MRI may help differentiate gliomas with different aggressiveness. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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