Alcohol consumption during adolescence is associated with reduced grey matter volumes.
Background and aims Cognitive impairment has been associated with excessive alcohol use, but its neural basis is poorly understood. Chronic excessive alcohol use in adolescence may lead to neuronal loss and volumetric changes in the brain. Our objective was to compare the grey matter volumes of heav...
| Publicado en: | Addiction Vol. 112; no. 4; pp. 604 - 614 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121567735&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121567735 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Apr2017 vid: 112 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 121567735 121567735 121567735 10.1111/add.13697 121567735 ppf: 604 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Alcohol consumption during adolescence is associated with reduced grey matter volumes. aug: au: Heikkinen, Noora Niskanen, Eini Könönen, Mervi Tolmunen, Tommi Kekkonen, Virve Kivimäki, Petri Tanila, Heikki Laukkanen, Eila Vanninen, Ritva affil: Department of Clinical Radiology, Kuopio University Hospital, Kuopio Finland sug: subj: Alcohol Drinking In Adolescence Gray Matter Alcohol-Related Disorders Adolescence Brain Cerebral Cortex Finland Human Magnetic Resonance Imaging Temporal Lobe Young Adult Adult Clinical Assessment Tools Questionnaires Data Analysis Software Descriptive Statistics Interviews Male Female Chi Square Test T-Tests Mann-Whitney U Test P-Value Confidence Intervals Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Background and aims Cognitive impairment has been associated with excessive alcohol use, but its neural basis is poorly understood. Chronic excessive alcohol use in adolescence may lead to neuronal loss and volumetric changes in the brain. Our objective was to compare the grey matter volumes of heavy- and light-drinking adolescents. Design This was a longitudinal study: heavy-drinking adolescents without an alcohol use disorder and their light-drinking controls were followed-up for 10 years using questionnaires at three time-points. Magnetic resonance imaging was conducted at the last time-point. Setting The area near Kuopio University Hospital, Finland. Participants The 62 participants were aged 22-28 years and included 35 alcohol users and 27 controls who had been followed-up for approximately 10 years. Measurements Alcohol use was measured by the Alcohol Use Disorders Identification Test (AUDIT)-C at three time-points during 10 years. Participants were selected based on their AUDIT-C score. Magnetic resonance imaging was conducted at the last time-point. Grey matter volume was determined and compared between heavy- and light-drinking groups using voxel-based morphometry on three-dimensional T1-weighted magnetic resonance images using predefined regions of interest and a threshold of P < 0.05, with small volume correction applied on cluster level. Findings Grey matter volumes were significantly smaller among heavy-drinking participants in the bilateral anterior cingulate cortex, right orbitofrontal and frontopolar cortex, right superior temporal gyrus and right insular cortex compared to the control group ( P < 0.05, family-wise error-corrected cluster level). Conclusions Excessive alcohol use during adolescence appears to be associated with an abnormal development of the brain grey matter. Moreover, the structural changes detected in the insula of alcohol users may reflect a reduced sensitivity to alcohol's negative subjective effects. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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