Performance-based and Observational Assessments in Clinical Trials Across the Alzheimer's Disease Spectrum.
Assessment of the earlier stages of Alzheimer's disease requires different strategies than those previously developed for fully syndromal Alzheimer's disease. This challenge is further magnified in very early stages, where symptomatology may be minimal and functional deficits very subtle to absent....
| Publicado en: | Innovations in Clinical Neuroscience Vol. 14; no. 1/2; pp. 30 - 40 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Matrix Medical Communications, LLC
Jan/Feb2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121706386&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121706386 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 21588333 DAD5 jtl: Innovations in Clinical Neuroscience issn: 21588333 maglogo: N pubinfo: dt: Jan/Feb2017 vid: 14 iid: 1/2 pid: 33670 pub: Matrix Medical Communications, LLC place: West Chester, Pennsylvania artinfo: ui: 121706386 121706386 121706386 121706386 ppf: 30 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Performance-based and Observational Assessments in Clinical Trials Across the Alzheimer's Disease Spectrum. aug: au: HARVEY, PHILIP D. COSENTINO, STEPHANIE CURIEL, ROSIE GOLDBERG, TERRY E. KAYE, JEFFREY LOEWENSTEIN, DAVID MARSON, DANIEL SALMON, DAVID WESNES, KEITH POSNER, HOLLY affil: University of Miami Leonard Miller School of Medicine, Department of Psychiatry and Behavioral Sciences, Miami, Florida sug: subj: Alzheimer's Disease Clinical Trials Patient Assessment Methods Cognition Evaluation Functional Assessment Meetings ab: Assessment of the earlier stages of Alzheimer's disease requires different strategies than those previously developed for fully syndromal Alzheimer's disease. This challenge is further magnified in very early stages, where symptomatology may be minimal and functional deficits very subtle to absent. This paper reviews strategies for performance-based assessment of the early stages of Alzheimer's disease, including assessments of cognition, functional capacity, and social cognition. Meetings with an International Society for CNS Clinical Trials and Methodology working group served as the basis for this paper and its companion. The current state of the art of detection and staging-oriented assessments is presented, and information is provided regarding the practicality and validity of these approaches, with a special focus on their usefulness in clinical trials for new medication development. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|