Flaxseed reduces epithelial proliferation but does not affect basal cells in induced benign prostatic hyperplasia in rats.
Purpose: This study aimed to quantitatively and qualitatively evaluate the effects of a flaxseed-based diet on the histoarchitecture of the prostate of normal Wistar rats and of rats with induced BPH. Methods: The study included four experimental groups of ten animals each: casein control group (CCG...
| Publicado en: | European Journal of Nutrition Vol. 56; no. 3; pp. 1201 - 1211 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121742146&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121742146 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Apr2017 vid: 56 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121742146 121742146 121742146 10.1007/s00394-016-1169-1 121742146 ppf: 1201 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Flaxseed reduces epithelial proliferation but does not affect basal cells in induced benign prostatic hyperplasia in rats. aug: au: Amorim Ribeiro, Ilma Costa, Carlos Silva, Vivian Côrrea, Lanna Boaventura, Gilson Chagas, Mauricio affil: Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute , Federal Fluminense University , Rua Hernani Melo, 101, São Domingos, Niterói Rio de Janeiro 24210-130 Brazil sug: subj: Flaxseed Prostatic Hypertrophy Histology Methods Animal Studies Caseins Diet Epithelium Human Hyperplasia Male Models, Biological Rats Analysis of Variance Post Hoc Analysis Funding Source Male ab: Purpose: This study aimed to quantitatively and qualitatively evaluate the effects of a flaxseed-based diet on the histoarchitecture of the prostate of normal Wistar rats and of rats with induced BPH. Methods: The study included four experimental groups of ten animals each: casein control group (CCG), who were fed a casein-based diet; flaxseed control group (FCG), who were fed a flaxseed-based diet; hyperplasia-induced casein group (HICG), who were fed a casein-based diet; and hyperplasia-induced flaxseed group (HIFG), who were fed a flaxseed-based diet. Hyperplasia was induced by the subcutaneous implantation of silicone pellets containing testosterone propionate. After 20 weeks, the rats were euthanized and their prostate fixed in buffered formalin. Tissue sections were stained with HE, picrosirius red and immunostained for nuclear antigen p63. Histomorphometric analysis evaluated the epithelial thickness, epithelial area, individual luminal area, and total area of prostatic alveoli. Results: The mean epithelial thickness obtained for HIFG and HICG was 16.52 ± 1.65 and 20.58 ± 2.86 µm, respectively. The mean epithelial thickness in HICG was greater than that in the other groups tested. HIFG had a smaller epithelial thickness and lower percentage of papillary projections in the prostatic alveoli. No significant difference was observed between CCG and FCG. The total area and mean alveolar area showed no significant differences between the groups. The number of cells immunostained for p63 was not significantly different between the groups evaluated. Conclusion: These results suggest that flaxseed has a protective effect on the prostate epithelium in BPH-induced animals. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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