Fruit and vegetable intake and vitamin C transporter gene ( SLC23A2) polymorphisms in chronic lymphocytic leukaemia.
Purpose: There is currently no convincing epidemiological evidence that fruit and vegetable consumption, the primary source of vitamin C, plays a role in chronic lymphocytic leukaemia (CLL) aetiology. We hypothesized that variations in vitamin C dietary intake as well as in genetic variability in vi...
| Publicado en: | European Journal of Nutrition Vol. 56; no. 3; pp. 1123 - 1134 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121742153&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121742153 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Apr2017 vid: 56 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121742153 121742153 121742153 10.1007/s00394-016-1162-8 121742153 ppf: 1123 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Fruit and vegetable intake and vitamin C transporter gene ( SLC23A2) polymorphisms in chronic lymphocytic leukaemia. aug: au: Casabonne, Delphine Gracia, Esther Espinosa, Ana Bustamante, Mariona Benavente, Yolanda Robles, Claudia Costas, Laura Alonso, Esther Gonzalez-Barca, Eva Tardón, Adonina Dierssen-Sotos, Trinidad Vázquez, Eva Aymerich, Marta Campo, Elies Jiménez-Moleón, José Marcos-Gragera, Rafael Castaño-Vinyals, Gemma Aragones, Nuria Pollan, Marina Kogevinas, Manolis affil: Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, IDIBELL , Institut Català d'Oncologia , Av. Gran Via 199 - 203, 2º 08907 L'Hospitalet De Llobregat, Barcelona Spain sug: subj: Flavoring Agents Fruit Leukemia, Lymphocytic, Chronic Polymorphism, Genetic Vegetables Ascorbic Acid Diet Eating Behavior Human Risk Factors Vitamins Male Female Adult Middle Age Aged Aged, 80 and Over Interviews Genotype Logistic Regression One-Way Analysis of Variance Chi Square Test Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Purpose: There is currently no convincing epidemiological evidence that fruit and vegetable consumption, the primary source of vitamin C, plays a role in chronic lymphocytic leukaemia (CLL) aetiology. We hypothesized that variations in vitamin C dietary intake as well as in genetic variability in vitamin C transporter gene SLC23A2 could explain some inconsistencies in the literature. Methods: Fruit/vegetable/vitamin C consumption from food frequency questionnaires and six low-penetrance genetic susceptibility polymorphisms in vitamin C transporter gene SLC23A2 (rs1715364, rs6133175, rs1776948, rs6139587, rs369270 and rs6052937) were examined in 434 CLL cases and 1257 randomly selected controls from primary care centres with genetic data of whom 275 cases and 1094 controls having both diet and genetic information. Logistic regression models were used to estimate odds ratio (OR) and 95 % confidence intervals (CI). Results: CLL patients were more likely to have a higher fruit consumption than controls (highest versus lowest quartile in g/day OR: 1.48; 95 % CI: 1.00 to 2.18; P = 0.03), whereas no associations were found with vegetable or total vitamin C intake. Based on log-additive models, rs6133175_A > G (OR: 1.19, 95 % CI: 1.00 to 1.41; P = 0.05) and rs1776948_T > A (OR: 1.20; 95 %CI: 1.01 to 1.41; P = 0.04) were associated with CLL. The haplogenotype analysis (rs1715364, rs6133175) supported the genotype results. No gene-diet interactions in CLL remained statistically significant after correction for multiple testing. Conclusions: These data suggest that both fruit intake and genetic marker in SLC23A2 may play an independent role in CLL biology. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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