Doppler ultrasonography combined with transient elastography improves the non-invasive assessment of fibrosis in patients with chronic liver diseases.
Aims: Accurate clinical assessment of liver fibrosis is essential and the aim of our study was to compare and combine hemodynamic Doppler ultrasonography, liver stiffness by transient elastography, and non-invasive serum biomarkers with the degree of fibrosis confirmed by liver biopsy, and thereby t...
| Publicado en: | Medical Ultrasonography Vol. 19; no. 1; pp. 7 - 16 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Romanian Society of Ultrasonography in Medicine & Biology
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121780055&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121780055 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18444172 AX1S jtl: Medical Ultrasonography issn: 18444172 maglogo: N pubinfo: dt: Mar2017 vid: 19 iid: 1 pid: 57537 pub: Romanian Society of Ultrasonography in Medicine & Biology artinfo: ui: 121780055 121780055 NLM28180191 121780055 10.11152/mu-921 NLM28180191 121780055 ppf: 7 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Doppler ultrasonography combined with transient elastography improves the non-invasive assessment of fibrosis in patients with chronic liver diseases. aug: au: Alempijevic, Tamara Zec, Simon Nikolic, Vladimir Veljkovic, Aleksandar Stojanovic, Zoran Matovic, Vera Milosavljevic, Tomica affil: School of Medicine, University of Belgrade sug: subj: Liver Cirrhosis Ultrasonography Ultrasonography, Doppler Liver Liver Cirrhosis Blood Reproducibility of Results Aged Adult Liver Diseases Sensitivity and Specificity Male Young Adult ROC Curve Female Chronic Disease Middle Age Liver Diseases Blood Human Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Aims: Accurate clinical assessment of liver fibrosis is essential and the aim of our study was to compare and combine hemodynamic Doppler ultrasonography, liver stiffness by transient elastography, and non-invasive serum biomarkers with the degree of fibrosis confirmed by liver biopsy, and thereby to determine the value of combining non-invasive method in the prediction significant liver fibrosis.Material and Methods: We included 102 patients with chronic liver disease of various etiology. Each patient was evaluated using Doppler ultrasonography measurements of the velocity and flow pattern at portal trunk, hepatic and splenic artery, serum fibrosis biomarkers, and transient elastography. These parameters were then input into a multilayer perceptron artificial neural network with two hidden layers, and used to create models for predicting significant fibrosis.Results: According to METAVIR score, clinically significant fibrosis (≥F2) was detected in 57.8% of patients. A model based only on Doppler parameters (hepatic artery diameter, hepatic artery systolic and diastolic velocity, splenic artery systolic velocity and splenic artery Resistance Index), predicted significant liver fibrosis with a sensitivity and specificity of75.0% and 60.0%. The addition of unrelated non-invasive tests improved the diagnostic accuracy of Doppler examination. The best model for prediction of significant fibrosis was obtained by combining Doppler parameters, non-invasive markers (APRI, ASPRI, and FIB-4) and transient elastography, with a sensitivity and specificity of 88.9% and 100%.Conclusion: Doppler parameters alone predict the presence of ≥F2 fibrosis with fair accuracy. Better prediction rates are achieved by combining Doppler variables with non-invasive markers and liver stiffness by transient elastography. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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