Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study.
Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents' childhood academic de...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 47; no. 3; pp. 834 - 846 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121840903&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121840903 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Mar2017 vid: 47 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121840903 121840903 144168201 121840903 10.1007/s10803-016-2996-x 121840903 ppf: 834 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study. aug: au: Losh, Molly Martin, Gary Lee, Michelle Klusek, Jessica Sideris, John Barron, Sheila Wassink, Thomas affil: Department of Communication Sciences and Disorders , Northwestern University , Frances Searle, 2240 N Campus Dr. Evanston 60208 USA sug: subj: Autism Spectrum Disorder Familial and Genetic Biological Markers Parents Autism Spectrum Disorder Risk Factors Semi-Structured Interview Human Intelligence Tests Prospective Studies Intergenerational Relations Phenotype Funding Source Case Control Studies Speech and Language Assessment Iowa Male Female Middle Age Aged Adolescence Adult Child Scales Neuropsychological Tests Psychological Tests Personality Tests Language Tests P-Value Retrospective Design Reading Mathematics Middle Aged: 45-64 years Aged: 65+ years Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Male Female ab: Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents' childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents' childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development across domains predicted ASD endophenotypes in adulthood for parents, and the severity of clinical symptoms in children with ASD. These findings may mark childhood indicators of genetic liability to ASD in parents, that could inform understanding of the subclinical expression of ASD genetic liability. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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