Calciphylaxis and Martorell Hypertensive Ischemic Leg Ulcer: Same Pattern - One Pathophysiology.
This review presents a closer look at four diseases which are probably closely related to one another pathophysiologically: (a) calciphylaxis (distal pattern); (b) calciphylaxis (proximal pattern); (c) Martorell hypertensive ischemic leg ulcer; (d) calciphylaxis with normal renal and parathyroid fun...
| Publicado en: | Dermatology (10188665) Vol. 232; no. 5; pp. 523 - 534 |
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| Autor principal: | |
| Formato: | review Journal Article |
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Karger AG
Jan2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121908833&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121908833 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188665 NIG jtl: Dermatology (10188665) issn: 10188665 maglogo: N pubinfo: dt: Jan2017 vid: 232 iid: 5 pid: 2485 pub: Karger AG artinfo: ui: 121908833 121908833 NLM27622522 121908833 10.1159/000448245 NLM27622522 121908833 ppf: 523 ppct: 11 formats: tig: atl: Calciphylaxis and Martorell Hypertensive Ischemic Leg Ulcer: Same Pattern - One Pathophysiology. aug: au: Hafner, Jürg affil: Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland sug: subj: Calciphylaxis Etiology Leg Ulcer Etiology Infarction Complications Skin Blood Supply Calciphylaxis Pathology Leg Ulcer Pathology Anticoagulants Adverse Effects Hyperparathyroidism Complications Leg Ulcer Therapy Diabetes Mellitus Complications Calciphylaxis Therapy Hypertension Complications Vitamin K Antagonists and Inhibitors Scales ab: This review presents a closer look at four diseases which are probably closely related to one another pathophysiologically: (a) calciphylaxis (distal pattern); (b) calciphylaxis (proximal pattern); (c) Martorell hypertensive ischemic leg ulcer; (d) calciphylaxis with normal renal and parathyroid function (synonym: eutrophication). The four diseases have largely the same risk factors: (1) arterial hypertension, (2) diabetes mellitus (types 1 and 2), (3) secondary or tertiary hyperparathyroidism (in end-stage kidney disease) and (4) oral anticoagulation with vitamin K antagonists. They share the same clinical patterns: necrotizing livedo, skin infarctions at typical locations and acral gangrene in calciphylaxis. They also share the same histopathology: ischemic subcutaneous arteriolosclerosis and small-artery disease and 'miniaturizing' Mönckeberg medial calcinosis. The treatment concept for the acute phase of the diseases is also broadly similar. In addition to an optimized control of the cardiovascular risk factors, a proactive wound approach (necrosectomy, negative pressure wound treatment with vacuum dressings, and early skin grafts supported by systemic antibiotic therapy) leads most rapidly and effectively to a reduction of the initially severe wound pain, and finally to complete healing of the wound. Oral anticoagulation with vitamin K antagonists should be stopped. In extensive cases, the use of intravenous sodium thiosulfate is recommended. All four diagnoses are little known in the medical schools of most countries. The need to improve familiarity with these four closely related disorders is therefore great. In particular, the risk of confusion with pyoderma gangrenosum is a major diagnostic problem which can lead to false and even damaging treatment. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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