The Impact of Different Case Ascertainment Definitions on the Prevalence of Major Congenital Malformations and their Association with Asthma During Pregnancy.
Objectives To compare the prevalence of major malformations using different case ascertainment definitions and to evaluate their impact on maternal asthma-major malformations association. Methods A cohort of pregnancies with and without asthma between 1990 and 2010 was formed. We used two classifica...
| Publicado en: | Maternal & Child Health Journal Vol. 21; no. 3; pp. 616 - 626 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121919505&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121919505 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10927875 N9J jtl: Maternal & Child Health Journal issn: 10927875 maglogo: N pubinfo: dt: Mar2017 vid: 21 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121919505 121919505 121919505 10.1007/s10995-016-2147-1 121919505 ppf: 616 ppct: 10 formats: fmt: @attributes: type: P tig: atl: The Impact of Different Case Ascertainment Definitions on the Prevalence of Major Congenital Malformations and their Association with Asthma During Pregnancy. aug: au: Eltonsy, Sherif Forget, Amelie Blais, Lucie sug: subj: Asthma Complications Abnormalities Risk Factors Abnormalities Epidemiology Abnormalities Classification Abnormalities, Drug-Induced International Classification of Diseases Female Human Maternal Exposure Odds Ratio Pregnancy Pregnancy Complications Pregnancy Trimester, First Record Review Databases Descriptive Research Billing and Claims Quebec Descriptive Statistics Confidence Intervals Adult Sensitivity and Specificity Funding Source Infant Adult: 19-44 years Infant: 1-23 months Female ab: Objectives To compare the prevalence of major malformations using different case ascertainment definitions and to evaluate their impact on maternal asthma-major malformations association. Methods A cohort of pregnancies with and without asthma between 1990 and 2010 was formed. We used two classification methods: the Two step Congenital Malformation Classification (TCMC) and the Canadian Congenital Anomalies Surveillance System (CCASS). Within each method, three case definitions were compared: (1) ≥1 diagnosis in the hospital database; (2) ≥1 diagnosis in the hospital database or ≥2 in the medical claims; and (3) ≥1 diagnosis in the hospital database or ≥1 in the medical claims. We calculated the prevalence of major malformations and adjusted odds ratios (aORs) for maternal asthma association. Results Of 467,946 pregnancies, 12.3 % were with active asthma. The prevalence estimates were: TCMC 5.10-7.08 % and CCASS 7.03-10.57 %. Asthma-major malformations association was weaker with the CCASS (aOR 1.14-1.20) versus TCMC (aOR 1.22-1.26). Discussion The case ascertainment definitions with ≥1 hospitalization are likely to be the most reliable in similar administrative databases. The case ascertainment definition had a considerable impact on the prevalence of major malformations, but hardly influenced the aORs. Future studies should formally assess the validity of the case ascertainment definitions and allow generalizability to other maternal exposures. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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