Variation in risk and outcomes of Epstein-Barr virus-associated breast cancer by epidemiologic characteristics and virus detection strategies: an exploratory study.
Purpose: A relationship of Epstein-Barr virus (EBV) and breast cancer etiology and outcome may have clinical utility and potential to enhance understanding of tumor biology. Research to date has yielded variable results, likely reflecting differing virus detection assays and unaddressed epidemiologi...
| Publicado en: | Cancer Causes & Control Vol. 28; no. 4; pp. 273 - 288 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121919775&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121919775 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Apr2017 vid: 28 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121919775 121919775 143996536 NLM28229344 121919775 10.1007/s10552-017-0865-3 NLM28229344 121919775 ppf: 273 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Variation in risk and outcomes of Epstein-Barr virus-associated breast cancer by epidemiologic characteristics and virus detection strategies: an exploratory study. aug: au: Glaser, Sally Canchola, Alison Keegan, Theresa Clarke, Christina Longacre, Teri Gulley, Margaret Glaser, Sally L Canchola, Alison J Keegan, Theresa H M Clarke, Christina A Longacre, Teri A Gulley, Margaret L affil: Cancer Prevention Institute of California , 2201 Walnut Avenue, Suite 300 Fremont 94538 USA sug: subj: Breast Neoplasms Epidemiology Adenocarcinoma Epidemiology Epstein-Barr Virus Epstein-Barr Virus Infections Epidemiology Female Adult Young Adult Breast Neoplasms Pathology Middle Age Breast Neoplasms White Persons Prevalence Aged Risk Factors Hispanic Americans Adenocarcinoma Adenocarcinoma Pathology Aged, 80 and Over Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female ab: Purpose: A relationship of Epstein-Barr virus (EBV) and breast cancer etiology and outcome may have clinical utility and potential to enhance understanding of tumor biology. Research to date has yielded variable results, likely reflecting differing virus detection assays and unaddressed epidemiologic heterogeneity across studies.Methods: Applying our novel, five-target assay detection strategy in an exploratory study, we examined demographic, clinical, and tumor characteristics, and overall survival, associated with EBV positivity in breast adenocarcinomas from 59 non-Hispanic white and 68 Hispanic women sampled by age (<50, 50+) and stage (localized, regional/remote) and examined associations based on single assay targets.Results: EBV was localized only to lymphocytes. Nevertheless, viral prevalence, although low, varied across patient subgroups. Adjusted odds ratios (OR) for EBV positivity were lower for younger Hispanic than white women (p interaction = 0.05), and marginally higher for larger [OR (95% confidence intervals) 1.03 (1.00-1.05) per mm increase] and right-sided [2.8 (0.97-7.8)] tumors. In whites, ORs were marginally higher for larger tumors [1.04 (1.00-1.07)] and marginally lower for age 50+ [0.24 (0.06-1.03)]; in Hispanics, ORs were higher for ER negative [5.6 (1.1-30.5)], and marginally higher for right-sided, tumors [5.8 (0.94-36.2)]. Survival was suggestively poorer for EBV-positive than EBV-negative tumors in older women with localized disease. EBV associations differed across single assay targets, indicating variation in prior findings likely due to assay performance.Conclusions: The differing EBV associations by age and race/ethnicity suggest a non-random role of EBV in breast cancer and support further study using multi-target assays, relevant epidemiologic design, and a larger study sample. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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