Beneficial effects of a Coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women.
Background: To assess the effect of a 12-day treatment using a vaginal gel based on niosomes containing hyaluronic acid, ß-glucan, alpha-glucan oligosaccharide, Coriolus versicolor, Asian centella, Azadirachta indica and Aloe vera on vaginal microbiota, cervical epithelization and vaginal health.Met...
| Publicado en: | BMC Women's Health Vol. 17; pp. 1 - 7 |
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| Autores principales: | , , , |
| Formato: | clinical trial pictorial research tables/charts Journal Article |
| Publicado: |
BioMed Central
3/16/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122000231&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122000231 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14726874 1CIP jtl: BMC Women's Health issn: 14726874 maglogo: N pubinfo: dt: 3/16/2017 vid: 17 pid: 24147 pub: BioMed Central artinfo: ui: 122000231 122000231 NLM28302110 122000231 10.1186/s12905-017-0374-2 NLM28302110 122000231 ppf: 1 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Beneficial effects of a Coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women. aug: au: Palacios, Santiago Losa, Fernando Dexeus, Damián Cortés, Javier affil: Gynecology and Obstetrics Department, Instituto Palacios de Medicina y Salud de la Mujer, C/Antonio Acuña 9, E-28009 Madrid, Spain sug: subj: Vaginal Creams, Foams and Jellies Pharmacodynamics Vagina Microbiology Adult Spain Colposcopy Methods Microbiologic Phenomena Drug Effects Mucus Microbiology Pilot Studies Vaginal Creams, Foams and Jellies Administration and Dosage Vaginal Creams, Foams and Jellies Therapeutic Use Lactobacillus Data Analysis, Statistical Prospective Studies Female Clinical Trials Human Adult: 19-44 years Female ab: Background: To assess the effect of a 12-day treatment using a vaginal gel based on niosomes containing hyaluronic acid, ß-glucan, alpha-glucan oligosaccharide, Coriolus versicolor, Asian centella, Azadirachta indica and Aloe vera on vaginal microbiota, cervical epithelization and vaginal health.Methods: Open-label, prospective pilot study conducted in asymptomatic women in daily practice. Cervical epithelization was evaluated by colposcopy using an ectopy epithelization score (from 5: no ectopy to 1: severe ectopy and bleeding), vaginal microbiota using the VaginaStatus-Diagnostic test (Instiüt für Mikroökologie, Herborn, Germany) and further rated by the investigator using a 5-point Liker scale (from 5: normal to 1: very severe deterioration in which all evaluated species were altered), and vaginal health using the Vaginal Health Index.Results: In 21 women, a positive effect to improve epithelization of the cervical mucosa, with a mean score of 4.42 at the final visit as compared to 3.09 at baseline (P < 0.0001) (43% improvement). In 10 women, there was a trend of improving of vaginal microbiota status, with a mean score of 4.0 at the final visit vs. 3.3 at baseline (P = NS) (21.2% improvement). In 11 women, the Vaginal Health Index increased from 19.0 at baseline to 22.3 at the final visit (P = 0.007). The concentration of Lactobacillus spp. increased 54.5% of women and pH decreased from 4.32 to 4.09.Conclusions: These encouraging preliminary results provide the basis for designing a randomized controlled study, and for potential use in human papilloma virus infection.Trial Registration: ISRCTN77955077 . Registration date: February 15, 2017. Retrospectively registered. pubtype: Academic Journal doctype: clinical trial pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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