Endometrial cancer with cervical stromal invasion: diagnostic accuracy of diffusion-weighted and dynamic contrast enhanced MR imaging at 3T.
Objectives: To compare the diagnostic accuracy of diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging for detecting cervical stromal invasion in endometrial cancer.Methods: Eighty-three consecutive women with endometrial cancer underwent preoperative evaluatio...
| Publicado en: | European Radiology Vol. 27; no. 5; pp. 1867 - 1877 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
May2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122196863&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122196863 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2017 vid: 27 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122196863 122196863 143957574 NLM27631107 122196863 10.1007/s00330-016-4583-0 NLM27631107 122196863 ppf: 1867 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Endometrial cancer with cervical stromal invasion: diagnostic accuracy of diffusion-weighted and dynamic contrast enhanced MR imaging at 3T. aug: au: Lin, Gigin Huang, Yu-Ting Chao, Angel Lin, Yu-Chun Yang, Lan-Yan Wu, Ren-Chin Lu, Hsin-Ying Ng, Shu-Hang Ng, Koon-Kwan Lai, Chyong-Huey affil: Department of Medical Imaging and Intervention, Institute for Radiological Research, Chang Gung Memorial Hospital at Linkou and Chang Gung University, 5 Fuhsing St. Guishan Taiwan 33382 sug: subj: Endometrial Neoplasms Pathology Uterine Neoplasms Pathology Diagnosis, Differential Middle Age Preoperative Care Methods Magnetic Resonance Imaging Methods Neoplasm Invasiveness Aged Female Human Sensitivity and Specificity Contrast Media Aged, 80 and Over ROC Curve Adult Reproducibility of Results Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Adult: 19-44 years Female ab: Objectives: To compare the diagnostic accuracy of diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging for detecting cervical stromal invasion in endometrial cancer.Methods: Eighty-three consecutive women with endometrial cancer underwent preoperative evaluation in a 3-T unit, including T2-weighted, DW (b = 0 and 1000 s/mm2), and DCE MR imaging. Two radiologists independently assessed presence of cervical stromal invasion, with histopathological reference as gold standard.Results: For assessing cervical stromal invasion, the diagnostic accuracy, sensitivity, and specificity, respectively for Reader 1/Reader 2, were as follows: DW MR imaging- 95.2 %/91.6 %, 91.7 %/100 %, and 95.8 %/90.1 %; DCE MR imaging- 91.6 %/88 %, 58.3 %/50 %, and 97.2 %/94.4 %. The diagnostic performance of DW MR imaging (Reader 1: areas under the receiver operating characteristic curve (AUC) = 0.98; Reader 2: AUC = 0.97) was significantly higher than that of DCE MR imaging (p = 0.009 for Reader 2) or T2-weighted MR imaging (Reader 1: p = 0.006; Reader 2: p = 0.013). Patients with cervical stromal invasion showed a significantly greater canal width (p < 0.0001) and myometrial invasion extent (p = 0.006).Conclusions: DW MR imaging has superior diagnostic performance compared with DCE MR imaging in the detection of cervical stromal invasion.Key Points: • DWI demonstrates a higher accuracy than DCE in detecting cervical stromal invasion. • Tumour ADC values are similar between patients without or with cervical invasion. • Canal widening causes false-negativity on DCE and T2W but not on DWI. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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