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Screening for Key Pathways Associated with the Development of Osteoporosis by Bioinformatics Analysis.

Objectives. We aimed to find the key pathways associated with the development of osteoporosis. Methods. We downloaded expression profile data of GSE35959 and analyzed the differentially expressed genes (DEGs) in 3 comparison groups (old_op versus middle, old_op versus old, and old_op versus senescen...

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Published in:BioMed Research International Vol. 2017; pp. 1 - 9
Main Authors: Liu, Yanqing, Wang, Yueqiu, Zhang, Yanxia, Liu, Zhiyong, Xiang, Hongfei, Peng, Xianbo, Chen, Bohua, Jia, Guyou
Format: research tables/charts Journal Article
Published: Wiley-Blackwell 3/30/2017
Online Access:View this record in EBSCOhost
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      dt: 3/30/2017
      vid: 2017
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        122203169
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        10.1155/2017/8589347
        122203169
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        atl: Screening for Key Pathways Associated with the Development of Osteoporosis by Bioinformatics Analysis.
      aug:
        au:
          Liu, Yanqing
          Wang, Yueqiu
          Zhang, Yanxia
          Liu, Zhiyong
          Xiang, Hongfei
          Peng, Xianbo
          Chen, Bohua
          Jia, Guyou
        affil: Department of Geriatric Medicine, Jining No. 1 People’s Hospital, Jining, Shandong 272011, China
      sug:
        subj:
          Health Screening
          Osteoporosis
          Bioinformatics
          Human
          Gene Expression
          Data Analysis Software
          Bone Development
      ab: Objectives. We aimed to find the key pathways associated with the development of osteoporosis. Methods. We downloaded expression profile data of GSE35959 and analyzed the differentially expressed genes (DEGs) in 3 comparison groups (old_op versus middle, old_op versus old, and old_op versus senescent). KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analyses were carried out. Besides, Venn diagram analysis and gene functional interaction (FI) network analysis were performed. Results. Totally 520 DEGs, 966 DEGs, and 709 DEGs were obtained in old_op versus middle, old_op versus old, and old_op versus senescent groups, respectively. Lysosome pathway was the significantly enriched pathways enriched by intersection genes. The pathways enriched by subnetwork modules suggested that mitotic metaphase and anaphase and signaling by Rho GTPases in module 1 had more proteins from module. Conclusions. Lysosome pathway, mitotic metaphase and anaphase, and signaling by Rho GTPases may be involved in the development of osteoporosis. Furthermore, Rho GTPases may regulate the balance of bone resorption and bone formation via controlling osteoclast and osteoblast. These 3 pathways may be regarded as the treatment targets for osteoporosis.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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