Biomarker, Molecular, and Technologic Advances in Urologic Pathology, Oncology, and Imaging.
Urologic pathology is evolving rapidly. Emerging trends include the expanded diagnostic utility of biomarkers and molecular testing, as well as adapting to the plethora of technical advances occurring in genitourinary oncology, surgical practice, and imaging. We illustrate those trends by highlighti...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 141; no. 4; pp. 499 - 517 |
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| Autores principales: | , , , |
| Formato: | diagnostic images pictorial Journal Article |
| Publicado: |
College of American Pathologists
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122226706&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122226706 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Apr2017 vid: 141 iid: 4 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 122226706 122226706 122226706 10.5858/arpa.2016-0263-SA 122226706 ppf: 499 ppct: 18 formats: fmt: @attributes: type: P tig: atl: Biomarker, Molecular, and Technologic Advances in Urologic Pathology, Oncology, and Imaging. aug: au: Ellis, Carla L. Harik, Lara R. Cohen, Cynthia Osunkoya, Adeboye O. affil: Department of Pathology, Emory University School of Medicine, Atlanta, Georgia sug: subj: Biological Markers Urologic Neoplasms Diagnosis Immunohistochemistry Carcinoma, Renal Cell Pheochromocytoma Prostatic Neoplasms Genes Mutation Diagnosis, Differential Biopsy Cryotherapy Cystoscopy RNA Amyloidosis Staining and Labeling Robotic Surgical Procedures Minimally Invasive Procedures Magnetic Resonance Imaging Tomography, Emission-Computed Neoplasm Metastasis Diagnosis ab: Urologic pathology is evolving rapidly. Emerging trends include the expanded diagnostic utility of biomarkers and molecular testing, as well as adapting to the plethora of technical advances occurring in genitourinary oncology, surgical practice, and imaging. We illustrate those trends by highlighting our approach to the diagnostic workup of a few selected disease entities that pathologists may encounter, including newly recognized subtypes of renal cell carcinoma, pheochromocytoma, and prostate cancer, some of which harbor a distinctive chromosomal translocation, gene loss, or mutation. We illustrate applications of immunohistochemistry for differential diagnosis of needle core renal biopsies, intraductal carcinoma of the prostate, and amyloidosis and cite encouraging results from early studies using targeted gene expression panels to predict recurrence after prostate cancer surgery. At our institution, pathologists are working closely with urologic surgeons and interventional radiologists to explore the use of intraoperative frozen sections for margins and nerve sparing during robotic prostatectomy, to pioneer minimally invasive videoscopic inguinal lymphadenectomy, and to refine image-guided needle core biopsies and cryotherapy of prostate cancer as well as blue-light/fluorescence cystoscopy. This collaborative, multidisciplinary approach enhances clinical management and research, and optimizes the care of patients with urologic disorders. pubtype: Academic Journal doctype: diagnostic images pictorial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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