A journey through the microscopic ages of DNA replication.
Scientific discoveries and technological advancements are inseparable but not always take place in a coherent chronological manner. In the next, we will provide a seemingly unconnected and serendipitous series of scientific facts that, in the whole, converged to unveil DNA and its duplication. We wi...
| Publicado en: | Protoplasma Vol. 254; no. 3; pp. 1151 - 1163 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122278537&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122278537 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0033183X 2CF jtl: Protoplasma issn: 0033183X maglogo: N pubinfo: dt: May2017 vid: 254 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122278537 144032177 10.1007/s00709-016-1058-8 122278537 ppf: 1151 ppct: 12 formats: fmt: @attributes: type: P tig: atl: A journey through the microscopic ages of DNA replication. aug: au: Reinhart, Marius Cardoso, M. affil: Cell Biology and Epigenetics, Department of Biology, Technische Universität Darmstadt, Schnittspahnstrasse 10 64287 Darmstadt Germany sug: ab: Scientific discoveries and technological advancements are inseparable but not always take place in a coherent chronological manner. In the next, we will provide a seemingly unconnected and serendipitous series of scientific facts that, in the whole, converged to unveil DNA and its duplication. We will not cover here the many and fundamental contributions from microbial genetics and in vitro biochemistry. Rather, in this journey, we will emphasize the interplay between microscopy development culminating on super resolution fluorescence microscopy (i.e., nanoscopy) and digital image analysis and its impact on our understanding of DNA duplication. We will interlace the journey with landmark concepts and experiments that have brought the cellular DNA replication field to its present state. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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