Prevalence of aromatase inhibitor-induced arthralgia in breast cancer: a systematic review and meta-analysis.
Background: Although aromatase inhibitors have proven to be an effective treatment of hormone receptor-positive breast cancer in postmenopausal women, aromatase inhibitor-induced arthralgia (AIA) is an adverse event associated with low compliance with treatment. The aim of this literature study is t...
| Publicado en: | Supportive Care in Cancer Vol. 25; no. 5; pp. 1673 - 1687 |
|---|---|
| Autores principales: | , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
May2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122279615&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122279615 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: May2017 vid: 25 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122279615 122279615 143905947 NLM28204994 122279615 10.1007/s00520-017-3613-z NLM28204994 122279615 ppf: 1673 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Prevalence of aromatase inhibitor-induced arthralgia in breast cancer: a systematic review and meta-analysis. aug: au: Beckwée, David Leysen, Laurence Meuwis, Kaipo Adriaenssens, Nele Beckwée, David affil: Rehabilitation Sciences Research Department, Vrije Universiteit Brussel, Laarbeeklaan 103 1090 Brussels Belgium sug: subj: Breast Neoplasms Drug Therapy Arthralgia Chemically Induced Aromatase Inhibitors Adverse Effects Human Treatment Outcomes Prevalence Breast Neoplasms Pathology Female Meta Analysis Systematic Review Female ab: Background: Although aromatase inhibitors have proven to be an effective treatment of hormone receptor-positive breast cancer in postmenopausal women, aromatase inhibitor-induced arthralgia (AIA) is an adverse event associated with low compliance with treatment. The aim of this literature study is to assess the prevalence of AIA and to provide an overview of significant predictors for the development of AIA.Methods: A systematic review was conducted using PubMed, Cochrane Library and Web of Science. A meta-analysis was performed and heterogeneity has been investigated by moderator analyses. The meta-analysis was repeated with studies that were considered as best evidence, i.e. studies with an above-average score on the STROBE checklist.Results: Twenty-one studies (13,177 participants) were included. Prevalence rates ranged from 0.200 to 0.737. Meta-analysis resulted in a pooled estimate of 0.459 (95% CI = [0.397-0.520) with a high heterogeneity (I 2 = 98%). Moderator analysis showed no differences regarding heterogeneity. Predictors for the development of AIA included a body mass index of 25-30 kg/m2 (OR = 0.33), taxane-based chemotherapy (OR = 4.08), stage III cancer (OR = 0.32) and a duration of menopause of 5-10 years (OR = 1.10) or >10 years (OR = 0.44-3.29) (An OR <1 indicates a predictor of lower risk of AIA).Discussion: Despite the established benefits of AI, an important portion of the patients experiences AIA. More research is needed to investigate the efficacy of treatments such as exercise therapy for AIA. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|