Diffusion kurtosis imaging and diffusion-weighted imaging in assessment of liver fibrosis stage and necroinflammatory activity.
Purpose: To investigate and compare the diagnostic value of diffusion kurtosis imaging (DKI) with diffusion-weighted imaging (DWI) in assessing and quantifying hepatic fibrosis. Methods: Thirty rats were divided into the control group ( n = 6) and the fibrosis experimental groups ( n = 6 per group)...
| Publicado en: | Abdominal Radiology Vol. 42; no. 4; pp. 1176 - 1183 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122280500&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122280500 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Apr2017 vid: 42 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122280500 143920476 10.1007/s00261-016-0984-4 122280500 ppf: 1176 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Diffusion kurtosis imaging and diffusion-weighted imaging in assessment of liver fibrosis stage and necroinflammatory activity. aug: au: Sheng, Ruo Wang, He Yang, Li Jin, Kai Xie, Yan Chen, Cai Zeng, Meng affil: Department of Radiology, Zhongshan Hospital , Fudan University, Shanghai Institute of Medical Imaging , No. 180 Fenglin Road, Xuhui District Shanghai 200032 China sug: ab: Purpose: To investigate and compare the diagnostic value of diffusion kurtosis imaging (DKI) with diffusion-weighted imaging (DWI) in assessing and quantifying hepatic fibrosis. Methods: Thirty rats were divided into the control group ( n = 6) and the fibrosis experimental groups ( n = 6 per group) with CCl administration for 2, 4, 6, and 8 weeks. Liver fibrosis stage (S) and necroinflammatory activity grade (G) were histopathologically determined. DKI and DWI were performed; mean apparent diffusion (MD), mean kurtosis (MK), and apparent diffusion coefficient (ADC) values were calculated. DKI parameters were compared with ADC values according to G/S scores. Results: Strong inverse correlations were found between the degree of fibrosis and both MD and ADC ( r = −0.840 and r = −0.760), while only weak correlation existed in MK ( r = 0.405). ROC analyses demonstrated the AUC in MD, MK, and ADC of 0.862, 0.684, 0.817 for identifying mild and severe fibrosis, and 0.757, 0.675, 0.733 for non-cirrhosis and cirrhosis, respectively. The degree of fibrosis was significantly correlated with α-smooth muscle actin (α-SMA) ( P < 0.0001); α-SMA had strong inverse correlation with MD ( r = −0.723), moderate inverse correlation with ADC ( r = −0.613), and very weak correlation with MK ( r = 0.175). Additionally, MD was strongly correlated with the necroinflammatory activity ( r = −0.758), ADC was moderately correlated ( r = −0.492), and MK was weakly correlated ( r = 0.254). Conclusion: DKI may provide added information and serve as a valuable tool for the characterization and surveillance of liver fibrosis in a non-invasive manner. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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