Endocrine therapy initiation, discontinuation and adherence and breast imaging among 21-gene recurrence score assay-eligible women under age 65.
Background: Aside from chemotherapy utilization, limited data are available on the relationship between gene expression profiling (GEP) testing and breast cancer care. We assessed the relationship between GEP testing and additional variables and the outcomes of endocrine therapy initiation, disconti...
| Publicado en: | Breast Cancer Research Vol. 19; pp. 1 - 14 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
3/31/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122362896&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122362896 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14655411 8UYJ jtl: Breast Cancer Research issn: 14655411 maglogo: N pubinfo: dt: 3/31/2017 vid: 19 pid: 24147 pub: BioMed Central artinfo: ui: 122362896 122362896 NLM28359319 122362896 10.1186/s13058-017-0837-2 NLM28359319 122362896 ppf: 1 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Endocrine therapy initiation, discontinuation and adherence and breast imaging among 21-gene recurrence score assay-eligible women under age 65. aug: au: O'Neill, Suzanne C. Isaacs, Claudine Lynce, Filipa Graham, Deena Mary Atieh Chao, Calvin Sheppard, Vanessa B. Yingjun Zhou Chunfu Liu Selvam, Nandini Schwartz, Marc D. Potosky, Arnold L. Zhou, Yingjun Liu, Chunfu affil: Georgetown Lombardi Comprehensive Cancer Center, 3300 Whitehaven Street, NW, Suite 4100, Washington, DC 20007, USA sug: subj: Gene Expression Profiling Breast Neoplasms Odds Ratio Aged, 80 and Over Neoplasm Staging Aged Breast Neoplasms Mortality Chemotherapy, Adjuvant Female Recurrence Young Adult Kaplan-Meier Estimator Breast Neoplasms Drug Therapy Adult Medication Compliance Middle Age Age Factors Risk Factors Funding Source Human Aged, 80 & over Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Female ab: Background: Aside from chemotherapy utilization, limited data are available on the relationship between gene expression profiling (GEP) testing and breast cancer care. We assessed the relationship between GEP testing and additional variables and the outcomes of endocrine therapy initiation, discontinuation and adherence, and breast imaging exams in women under age 65 years.Methods: Data from five state cancer registries were linked with claims data and GEP results. We assessed variables associated with survivorship care outcomes in an incident cohort of 5014 commercially insured women under age 65 years, newly diagnosed with stage I or II hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2) non-positive breast cancer from 2006 to 2010.Results: Among tested women, those with high Oncotype DX® Breast Recurrence Score® (RS) were significantly less likely to initiate endocrine therapy than women with low RS tumors (OR 0.40 (95% CI 0.20 to 0.81); P = 0.01). Among all test-eligible women, receipt of Oncotype DX testing was associated with a greater likelihood of endocrine therapy initiation (OR 2.48 (95% CI 2.03 to 3.04); P <0.0001). The odds of initiation were also significantly higher for tested vs. untested women among women who did not initiate chemotherapy within six months of diagnosis (OR 3.25 (95% CI 2.53 to 4.16)), with no effect in women who received chemotherapy. Discontinuation and adherence and breast imaging exams were unrelated to tested status or RS.Conclusions: Lower endocrine therapy initiation rates among women with high RS tumors and among untested women not receiving chemotherapy are concerning, given its established efficacy. Additional research is needed to suggest mechanisms to close this gap. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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