Postsynaptic density protein transcripts are differentially modulated by minocycline alone or in add-on to haloperidol: Implications for treatment resistant schizophrenia.
In this study, we investigated whether minocycline, a second-generation tetracycline proposed as an add-on to antipsychotics in treatment-resistant schizophrenia (TRS), may affect the expression of Homer and Arc postsynaptic density (PSD) transcripts, implicated in synaptic regulation. Minocycline w...
| Publicado en: | Journal of Psychopharmacology Vol. 31; no. 4; pp. 406 - 418 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122379719&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122379719 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02698811 3FD jtl: Journal of Psychopharmacology issn: 02698811 maglogo: Y pubinfo: dt: Apr2017 vid: 31 iid: 4 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 122379719 122379719 NLM27443599 122379719 10.1177/0269881116658987 NLM27443599 122379719 ppf: 406 ppct: 12 formats: tig: atl: Postsynaptic density protein transcripts are differentially modulated by minocycline alone or in add-on to haloperidol: Implications for treatment resistant schizophrenia. aug: au: Buonaguro, Elisabetta F. Tomasetti, Carmine Chiodini, Paolo Marmo, Federica Latte, Gianmarco Rossi, Rodolfo Avvisati, Livia Iasevoli, Felice de Bartolomeis, Andrea affil: Department of Neuroscience, Reproductive Sciences and Odontostomatology, University School of Medicine 'Federico II', Naples, Italy sug: subj: Cell Membrane Structures Drug Effects Haloperidol Pharmacodynamics Nerve Tissue Proteins Metabolism Minocycline Pharmacodynamics Schizophrenia Drug Therapy Drug Resistance Antipsychotic Agents Pharmacodynamics Cell Membrane Structures Metabolism Male Membrane Proteins Metabolism Gene Expression Drug Effects Psychotic Disorders Drug Therapy Animal Studies Ketamine Pharmacodynamics Rats Schizophrenia Metabolism Cerebral Cortex Drug Effects Psychotic Disorders Metabolism Receptors, Cell Surface Metabolism Cerebral Cortex Metabolism Intracellular Signaling Peptides and Proteins Metabolism Male ab: In this study, we investigated whether minocycline, a second-generation tetracycline proposed as an add-on to antipsychotics in treatment-resistant schizophrenia (TRS), may affect the expression of Homer and Arc postsynaptic density (PSD) transcripts, implicated in synaptic regulation. Minocycline was administered alone or with haloperidol in rats exposed or not to ketamine, mimicking acute glutamatergic psychosis or naturalistic conditions, respectively. Arc expression was significantly reduced by minocycline compared with controls. Minocycline in combination with haloperidol also significantly reduced Arc expression compared with both controls and haloperidol alone. Moreover, haloperidol/minocycline combination significantly affected Arc expression in cortical regions, while haloperidol alone was ineffective on cortical gene expression. These results suggest that minocycline may strongly affect the expression of Arc as mediated by haloperidol, both in terms of quantitative levels and of topography of haloperidol-related expression. It is noteworthy that no significant pre-treatment effect was found, suggesting that pre-exposure to ketamine did not grossly affect gene expression. Minocycline was not found to significantly affect haloperidol-related Homer1a expression. No significant changes in Homer1b/c expression were observed. These results are consistent with previous observations that minocycline may modulate postsynaptic glutamatergic transmission, affecting distinct downstream pathways initiated by N-methyl-D-aspartate (NMDA) receptor modulation, i.e. Arc-mediated but not Homer1a-mediated pathways. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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