Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory study.
In this exploratory case-control study, we investigated basal cortisol regulation in 5-16-year-old children, 3-6 months following PICU (paediatric intensive care) admission. This was nested within a study of child psychological and cognitive function; 47 children were assessed alongside 56 healthy c...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 26; no. 5; pp. 511 - 520 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122540563&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122540563 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: May2017 vid: 26 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122540563 122540563 143950530 122540563 10.1007/s00787-016-0933-3 122540563 ppf: 511 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory study. aug: au: Als, Lorraine Picouto, Maria O'Donnell, Kieran Nadel, Simon Cooper, Mehrengise Pierce, Christine Kramer, Tami Glover, Vivette Garralda, M. affil: Department of Medicine, Centre for Mental Health , Imperial College London , Hammersmith Hospital Campus, 7th Floor Commonwealth Building, Du Cane Road London W12 0NN UK sug: subj: Critical Illness Stress Disorders, Post-Traumatic Hydrocortisone Analysis Pediatric Care Human Exploratory Research Case Control Studies Child Child, Preschool Adolescence Saliva Analysis Scales Secondary Analysis Intensive Care Units, Pediatric Walking Multivariate Analysis Child: 6-12 years Child, Preschool: 2-5 years Adolescent: 13-18 years ab: In this exploratory case-control study, we investigated basal cortisol regulation in 5-16-year-old children, 3-6 months following PICU (paediatric intensive care) admission. This was nested within a study of child psychological and cognitive function; 47 children were assessed alongside 56 healthy controls. Saliva samples were collected three times per day (immediately after waking, waking +30 min, and waking +12 h) over two consecutive weekdays. In addition, data on posttraumatic stress symptoms were ascertained from 33 PICU admitted children using the Impact of Events Scale-8 (IES-8). Primary analysis revealed no significant differences in basal cortisol concentrations between PICU discharged children and healthy controls ( p > 0.05). Secondary analysis in the PICU group identified a significant positive association between posttraumatic stress symptoms and evening (waking +12 h) cortisol concentrations ( p = 0.004). However, when subject to multivariate analysis, evening cortisol was a modest independent predictor of IES-8 scores, relative to the presence of septic illness and poor pre-morbid health. We conclude that paediatric critical illness does not appear to result in marked perturbations to basal cortisol at 3-6 month following discharge. There was evidence of a link between evening cortisol and symptoms of PTSD, but this was not a robust effect and requires further elucidation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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