MR imaging differentiation of Fe and Fe based on relaxation and magnetic susceptibility properties.
Purpose: The aim of this study is to evaluate the MR imaging behavior of ferrous (Fe) and ferric (Fe) iron ions in order to develop a noninvasive technique to quantitatively differentiate between both forms of iron. Methods: MRI was performed at 3 T in a phantom consisting of 21 samples with differe...
| Publicado en: | Neuroradiology Vol. 59; no. 4; pp. 403 - 410 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122540845&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122540845 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Apr2017 vid: 59 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122540845 122540845 144173430 122540845 10.1007/s00234-017-1813-3 122540845 ppf: 403 ppct: 7 formats: fmt: @attributes: type: P tig: atl: MR imaging differentiation of Fe and Fe based on relaxation and magnetic susceptibility properties. aug: au: Dietrich, Olaf Levin, Johannes Ahmadi, Seyed-Ahmad Plate, Annika Reiser, Maximilian Bötzel, Kai Giese, Armin Ertl-Wagner, Birgit affil: Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology , Ludwig-Maximilians-University Hospital Munich , Marchioninistr. 15 81377 Munich Germany sug: subj: Magnetic Resonance Imaging Ferrous Compounds Analysis Ferric Compounds Analysis Ions Diagnostic Imaging Evaluation Phantoms, Imaging Quantitative Studies Electromagnetics ab: Purpose: The aim of this study is to evaluate the MR imaging behavior of ferrous (Fe) and ferric (Fe) iron ions in order to develop a noninvasive technique to quantitatively differentiate between both forms of iron. Methods: MRI was performed at 3 T in a phantom consisting of 21 samples with different concentrations of ferrous and ferric chloride solutions (between 0 and 10 mmol/L). A multi-echo spoiled gradient-echo pulse sequence with eight echoes was used for both T * and quantitative susceptibility measurements. The transverse relaxation rate, R * = 1/ T *, was determined by nonlinear exponential fitting based on the mean signals in each sample. The susceptibilities, χ, of the samples were calculated after phase unwrapping and background field removal by fitting the spatial convolution of a unit dipole response to the measured internal field map. Relaxation rate changes, Δ R *( c ), and susceptibility changes, Δ χ( c ), their linear slopes, as well as the ratios Δ R *( c ) / Δ χ( c ) were determined for all concentrations. Results: The linear slopes of the relaxation rate were (12.5 ± 0.4) s/(mmol/L) for Fe and (0.77 ± 0.09) s/(mmol/L) for Fe (significantly different, z test P < 0.0001). The linear slopes of the susceptibility were (0.088 ± 0.003) ppm/(mmol/L) for Fe and (0.079 ± 0.006) ppm/(mmol/L) for Fe. The individual ratios Δ R */Δ χ were greater than 40 s/ppm for all samples with ferric solution and lower than 20 s/ppm for all but one of the samples with ferrous solution. Conclusion: Ferrous and ferric iron ions show significantly different relaxation behaviors in MRI but similar susceptibility patterns. These properties can be used to differentiate ferrous and ferric samples. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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