The structural connectome in children: basic concepts, how to build it, and synopsis of challenges for the developing pediatric brain.
Purpose: The structural connectome is a comprehensive structural description of the network of elements and connections forming the brain. In recent years, this framework has progressively been used to investigate the pediatric brain. Methods: We discuss the different steps and emphasize key technic...
| Publicado en: | Neuroradiology Vol. 59; no. 5; pp. 445 - 461 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images pictorial review tables/charts Journal Article |
| Publicado: |
Springer Nature
May2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122560498&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122560498 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: May2017 vid: 59 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122560498 122560498 144149640 122560498 10.1007/s00234-017-1831-1 122560498 ppf: 445 ppct: 16 formats: fmt: @attributes: type: P tig: atl: The structural connectome in children: basic concepts, how to build it, and synopsis of challenges for the developing pediatric brain. aug: au: Meoded, Avner Huisman, Thierry Casamassima, Maria Jallo, George Poretti, Andrea affil: Department of Radiology, Johns Hopkins All Children's Hospital , The Johns Hopkins University School of Medicine , 501 6th Avenue South St. Petersburg 33701 USA sug: subj: Brain Anatomy and Histology Neural Pathways Anatomy and Histology Magnetic Resonance Imaging Methods Imaging, Three-Dimensional Child Brain Mapping Methods Child: 6-12 years ab: Purpose: The structural connectome is a comprehensive structural description of the network of elements and connections forming the brain. In recent years, this framework has progressively been used to investigate the pediatric brain. Methods: We discuss the different steps and emphasize key technical aspects required for the successful reconstruction, analysis, and visualization of the pediatric structural connectome using current state-of-the-art neuroimaging and post-processing techniques. Results: The two key components of structural connectome are a node (a cortical region obtained with high-resolution anatomical imaging) and an edge (structural association between cortical regions, defined with tractography). After delineation of nodes and edges, an association matrix can be generated by compiling all pairwise associations between nodes and applying a threshold to produce a binary adjacency matrix. Several measures can be used to characterize the topological architecture of the brain's networks. Finally, we provide an overview of various visualization methods of the structural connectome in children. Conclusion: The human connectome is the culmination of more than a century of conceptual and methodological innovation. Biological substrates of brain development such as cortical gyration and myelination challenge the acquisition, reconstruction, and analysis of structural connectome in children and require specific considerations compared to adults. pubtype: Academic Journal doctype: diagnostic images pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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