Liver fibrosis: Review of current imaging and MRI quantification techniques.
Liver fibrosis is characterized by the accumulation of extracellular matrix proteins such as collagen in the liver interstitial space. All causes of chronic liver disease may lead to fibrosis and cirrhosis. The severity of liver fibrosis influences the decision to treat or the need to monitor hepati...
| Publicado en: | Journal of Magnetic Resonance Imaging Vol. 45; no. 5; pp. 1276 - 1296 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
May2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122561713&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122561713 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10531807 O63 jtl: Journal of Magnetic Resonance Imaging issn: 10531807 maglogo: Y pubinfo: dt: May2017 vid: 45 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 122561713 122561713 NLM27981751 122561713 10.1002/jmri.25550 NLM27981751 122561713 ppf: 1276 ppct: 20 formats: tig: atl: Liver fibrosis: Review of current imaging and MRI quantification techniques. aug: au: Petitclerc, Léonie Sebastiani, Giada Gilbert, Guillaume Cloutier, Guy Tang, An affil: Department of Radiology, Radio‐Oncology and Nuclear Medicine, Université de Montréal, Montreal Quebec, Canada sug: subj: Liver Cirrhosis Ultrasonography Methods Magnetic Resonance Imaging Methods Perfusion Viscosity Liver Cirrhosis Pathology Human Elasticity Biopsy Liver Diseases Pathology Contrast Media Liver Pathology ab: Liver fibrosis is characterized by the accumulation of extracellular matrix proteins such as collagen in the liver interstitial space. All causes of chronic liver disease may lead to fibrosis and cirrhosis. The severity of liver fibrosis influences the decision to treat or the need to monitor hepatic or extrahepatic complications. The traditional reference standard for diagnosis of liver fibrosis is liver biopsy. However, this technique is invasive, associated with a risk of sampling error, and has low patient acceptance. Imaging techniques offer the potential for noninvasive diagnosis, staging, and monitoring of liver fibrosis. Recently, several of these have been implemented on ultrasound (US), computed tomography, or magnetic resonance imaging (MRI). Techniques that assess changes in liver morphology, texture, or perfusion that accompany liver fibrosis have been implemented on all three imaging modalities. Elastography, which measures changes in mechanical properties associated with liver fibrosis-such as strain, stiffness, or viscoelasticity-is available on US and MRI. Some techniques assessing liver shear stiffness have been adopted clinically, whereas others assessing strain or viscoelasticity remain investigational. Further, some techniques are only available on MRI-such as spin-lattice relaxation time in the rotating frame (T1 ρ), diffusion of water molecules, and hepatocellular function based on the uptake of a liver-specific contrast agent-remain investigational in the setting of liver fibrosis staging. In this review, we summarize the key concepts, advantages and limitations, and diagnostic performance of each technique. The use of multiparametric MRI techniques offers the potential for comprehensive assessment of chronic liver disease severity.Level Of Evidence: 5 J. MAGN. RESON. IMAGING 2017;45:1276-1295. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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