Effects of subclinical depression, anxiety and somatization on brain structure in healthy subjects.
Background: Dimensional approaches in highly prevalent psychiatric disorders like depression or anxiety could lead to a better understanding of pathogenesis and advantages in early detection and prevention. In an effort to better understand associations of brain structural variation across the depre...
| Publicado en: | Journal of Affective Disorders Vol. 215; pp. 111 - 118 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jun2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122585055&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122585055 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01650327 3M9 jtl: Journal of Affective Disorders issn: 01650327 maglogo: N pubinfo: dt: Jun2017 vid: 215 pid: 1004 pub: Elsevier B.V. artinfo: ui: 122585055 122585055 NLM28319687 122585055 10.1016/j.jad.2017.03.039 NLM28319687 122585055 ppf: 111 ppct: 7 formats: tig: atl: Effects of subclinical depression, anxiety and somatization on brain structure in healthy subjects. aug: au: Besteher, Bianca Gaser, Christian Langbein, Kerstin Dietzek, Maren Sauer, Heinrich Nenadić, Igor affil: Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany sug: subj: Anxiety Pathology Gray Matter Pathology Research Subjects Psychosocial Factors Somatoform Disorders Pathology Cerebral Cortex Pathology Cerebellum Pathology Depression Pathology Young Adult Male Early Diagnosis Adult Magnetic Resonance Imaging Brain Mapping Female Checklists Symptom Checklist-90-Revised Human Scales Adult: 19-44 years Male Female ab: Background: Dimensional approaches in highly prevalent psychiatric disorders like depression or anxiety could lead to a better understanding of pathogenesis and advantages in early detection and prevention. In an effort to better understand associations of brain structural variation across the depression/anxiety spectra, we investigated minor subclinical symptoms in a non-clinical healthy population.Methods: We studied 177 healthy subjects from the community, who underwent high-resolution T1-weighted 3T MRI and completed the symptom-checklist-90 (SCL-90-R). Using voxel-based morphometry (VBM) analysis with CAT12 software, we correlated SCL-90-R-subscales for depression, anxiety, and somatization with gray matter across the brain.Results: Significant positive gray matter correlations emerged across all three scales in different areas: the depression subscale correlated positively with gray matter in the Rolandic operculum, superior temporal gyrus (left) and postcentral gyrus (bilateral), the anxiety subscale correlated positively with middle temporal gyrus, Rolandic operculum, middle cingular gyrus and precuneus bilaterally, and the somatization subscale with left inferior prefrontal cortex. Somatization also showed negative correlations with cerebellar vermis and right supplementary motor area.Limitations: Our study is limited to VBM and does not include surface-based measures. It also only contains subjects with very small psychological distress by partly overlapping symptoms.Conclusion: Our findings are consistent with a non-linear relationship between symptom severity and cortical volume in several brain areas involved in both emotion regulation as well as altered in clinically manifest depressive/anxiety disorders. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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