Central noradrenaline transporter availability in highly obese, non-depressed individuals.
Purpose: The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate. Me...
| Published in: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 44; no. 6; pp. 1056 - 1065 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Jun2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122598646&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122598646 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Jun2017 vid: 44 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122598646 144044019 10.1007/s00259-016-3590-3 122598646 ppf: 1056 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Central noradrenaline transporter availability in highly obese, non-depressed individuals. aug: au: Hesse, Swen Becker, Georg-Alexander Rullmann, Michael Bresch, Anke Luthardt, Julia Hankir, Mohammed Zientek, Franziska Reißig, Georg Patt, Marianne Arelin, Katrin Lobsien, Donald Müller, Ulrich Baldofski, S. Meyer, Philipp Blüher, Matthias Fasshauer, Mathias Fenske, Wiebke Stumvoll, Michael Hilbert, Anja Ding, Yu-Shin affil: Department of Nuclear Medicine , University of Leipzig , Liebigstraße 18 04103 Leipzig Germany sug: ab: Purpose: The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate. Methods: We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S,S-[C]O-methylreboxetine (MRB) in twenty subjects comprising ten highly obese (body mass index BMI > 35 kg/m), metabolically healthy, non-depressed individuals and ten non-obese (BMI < 30 kg/m) healthy controls. Results: Overall, we found no significant differences in binding potential (BP) values between obese and non-obese individuals in the investigated brain regions, including the NAT-rich thalamus (0.40 ± 0.14 vs. 0.41 ± 0.18; p = 0.84) though additional discriminant analysis correctly identified individual group affiliation based on regional BP in all but one (control) case. Furthermore, inter-regional correlation analyses indicated different BP patterns between both groups but this did not survive testing for multiple comparions. Conclusions: Our data do not find an overall involvement of NAT changes in human obesity. However, preliminary secondary findings of distinct regional and associative patterns warrant further investigation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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