Correlation Between Mesopic Retinal Sensitivity and Optical Coherence Tomographic Metrics of the Outer Retina in Patients With Non-Atrophic Dry Age-Related Macular Degeneration.
Background and Objective: To determine the correlation between mesopic retinal sensitivity and optical coherence tomographic metrics of the outer retina in patients with intermediate age-related macular degeneration (AMD).Patients and Methods: Participants with nonatrophic dry AMD underwent mesopic...
| Publicado en: | Ophthalmic Surgery, Lasers & Imaging Retina Vol. 48; no. 4; pp. 312 - 319 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
SLACK Incorporated
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122631243&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122631243 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23258160 FSW0 jtl: Ophthalmic Surgery, Lasers & Imaging Retina issn: 23258160 maglogo: N pubinfo: dt: Apr2017 vid: 48 iid: 4 pid: 1693 pub: SLACK Incorporated place: Thorofare, New Jersey artinfo: ui: 122631243 122631243 NLM28419396 122631243 10.3928/23258160-20170329-05 NLM28419396 122631243 ppf: 312 ppct: 7 formats: tig: atl: Correlation Between Mesopic Retinal Sensitivity and Optical Coherence Tomographic Metrics of the Outer Retina in Patients With Non-Atrophic Dry Age-Related Macular Degeneration. aug: au: Tepelus, Tudor C. Hariri, Amir H. Al-Sheikh, Mayss Sadda, SriniVas R. affil: Doheny Image Reading Center, Doheny Eye Institute, Los Angeles sug: subj: Macular Degeneration Physiopathology Eye Movements Physiology Visual Acuity Algorithms Tomography, Optical Coherence Methods Retina Photoreceptors Pathology Macular Degeneration Diagnosis Prospective Studies Aged, 80 and Over Aged Female Physical Stimulation Male Human Aged, 80 & over Aged: 65+ years Female Male ab: Background and Objective: To determine the correlation between mesopic retinal sensitivity and optical coherence tomographic metrics of the outer retina in patients with intermediate age-related macular degeneration (AMD).Patients and Methods: Participants with nonatrophic dry AMD underwent mesopic MP-3 microperimetry (Nidek, Padova, Italy) and both Nidek and Cirrus (Carl Zeiss Meditec, Dublin, CA) spectral-domain optical coherence tomography (SD-OCT). The volume of the outer retinal layers was measured on the Nidek SD-OCT scans using the automatic segmentation algorithm of Navis-EX software. In addition, drusen area and volume within a 5-mm circle centered on the fovea were determined using the Cirrus Advanced RPE Analysis Tool. The mean retinal sensitivity at 8° and 10° of fixation (5-mm and 6-mm circles) was calculated for every eye. The correlation between retinal sensitivity and patient age, outer retinal layer volume, drusen area, and drusen volume was assessed.Results: Thirty-seven eyes from 25 patients with non-atrophic dry AMD were included in the study. The mean age of the patients was 76 years ± 9 years. The mean sensitivity across the whole tested retinal area was 24.9 dB ± 2.4 dB, with a sensitivity of 25.1 dB ± 2.4 dB within the central 5-mm circle. Drusen area within the central 5-mm circle was 0.7 mm2 ± 0.89 mm2 with a drusen volume of 0.03 mm3 ± 0.04 mm3. Retinal pigment epithelium and photoreceptor outer segment (RPE + OS) volume was 1.96 mm3 ± 0.1 mm3, and outer nuclear layer (ONL) volume was 1.91 mm3 ± 0.17 mm3. There was a significant correlation between RPE + OS volume and retinal sensitivity, as well as between patients' age and retinal sensitivity. There was no significant correlation between drusen area or volume and retinal sensitivity, nor between ONL volume and retinal sensitivity.Conclusion: In eyes with nonatrophic AMD, retinal sensitivity is correlated with the RPE + OS volume, but not the ONL volume or the area or volume of drusen. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:312-318.]. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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