Performance of 2D-SWE.GE for predicting different stages of liver fibrosis, using Transient Elastography as the reference method.
Aim: To evaluate the performance of 2D shear-wave elastography from General Electric (2D-SWE.GE) for the noninvasiveassessment of liver fibrosis and to identify liver stiffness (LS) cut-off values for predicting different stages of fibrosisusing Transient Elastography (TE) as the reference method.Ma...
| Publicado en: | Medical Ultrasonography Vol. 19; no. 2; pp. 143 - 150 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Romanian Society of Ultrasonography in Medicine & Biology
Jun2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122697599&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122697599 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18444172 AX1S jtl: Medical Ultrasonography issn: 18444172 maglogo: N pubinfo: dt: Jun2017 vid: 19 iid: 2 pid: 57537 pub: Romanian Society of Ultrasonography in Medicine & Biology artinfo: ui: 122697599 122697599 NLM28440347 10.11152/mu-910 NLM28440347 122697599 ppf: 143 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Performance of 2D-SWE.GE for predicting different stages of liver fibrosis, using Transient Elastography as the reference method. aug: au: Bende, Felix Sporea, Ioan Şirli, Roxana Popescu, Alina Mare, Ruxandra Miuţescu, Bogdan Lupuşoru, Raluca Moga, Tudor Pienar, Corina Sirli, Roxana Miutescu, Bogdan Lupusoru, Raluca affil: Department of Gastroenterology and Hepatology, "Victor Babeş" University of Medicine and Pharmacy Timişoara, Romania sug: subj: Liver Cirrhosis Physiopathology Liver Image Interpretation, Computer Assisted Methods Ultrasonography Methods Liver Physiopathology Liver Cirrhosis Disease Progression Female Adult Young Adult Aged Reproducibility of Results Severity of Illness Indices Male Aged, 80 and Over Biomechanics Elasticity Middle Age Sensitivity and Specificity Questionnaires Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Aim: To evaluate the performance of 2D shear-wave elastography from General Electric (2D-SWE.GE) for the noninvasiveassessment of liver fibrosis and to identify liver stiffness (LS) cut-off values for predicting different stages of fibrosisusing Transient Elastography (TE) as the reference method.Material and Method: We included 331 consecutive subjectswith or without chronic hepatopathies in whom LS was evaluated in the same session by means of 2 elastographic techniques:TE and 2D-SWE.GE. Reliable LS measurements were defined for TE as the median value of 10 measurements with a successrate of ≥60% and an interquartile range (IQR)<30% and for 2D-SWE.GE as the median value of 10 measurements acquiredin a homogenous area and an IQR<30%. To discriminate between TE fibrosis stages we used the following cut-offs: F2- 7;F3- 9.5 and F4- 12kPa.Results: Reliable LS measurements were obtained in 95.8% subjects by 2D-SWE.GE, and 94.2%by TE (p=0.44). Based on TE cut-off values we divided our cohort into four groups: F<2: 30.1%; F=2: 10.2%; F=3: 12.2%;F=4: 47.5%. A strong correlation was found between the LS values obtained by the 2 methods: r=0.83, p<0.0001.LS valuesobtained by 2D-SWE.GE were significantly lower than those obtained by TE: 10.14±4.24 kPa vs. 16.72±13.4 kPa (p<0.0001).The best cut-off value for F≥2, F≥3 and for F=4 were 6.7, 8.2 and 9.3 kPa.Conclusions: The best 2D-SWE.GE cut-off valuesfor predicting F≥2, F≥3 and F=4 were 6.7, 8.2 and 9.3kPa. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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