Overexpression of Rsf-1 correlates with poor survival and promotes invasion in non-small cell lung cancer.
Rsf-1 (HBXAP) was recently reported to play roles in tumorigenesis and tumor progression. There have been many reports referred to Rsf-1 overexpression in various cancers and associated with the malignant behavior of cancer cells. However, the molecular mechanism of Rsf-1 in non-small cell lung canc...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 470; no. 5; pp. 553 - 561 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122710499&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122710499 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: May2017 vid: 470 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122710499 122710499 144038009 NLM28289901 122710499 10.1007/s00428-017-2102-6 NLM28289901 122710499 ppf: 553 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Overexpression of Rsf-1 correlates with poor survival and promotes invasion in non-small cell lung cancer. aug: au: Zhang, Xiuwei Fu, Lin Xue, Dongwei Zhang, Xiupeng Hao, Fengxia Xie, Lingling He, Jiani Gai, Junda Liu, Yuhui Xu, Hongtao Li, Qingchang Wang, Enhua affil: Department of Pathology , The 1st Affiliated Hospital and College of Basic Medical Sciences of China Medical University , Shenyang 110001 People's Republic of China sug: subj: Lung Neoplasms Pathology Nuclear Proteins Proteins Carcinoma, Non-Small-Cell Lung Pathology Peptide Hydrolases Metabolism NF-kappa B Metabolism Lung Neoplasms Mortality Immunohistochemistry Neoplasm Invasiveness Pathology Genetic Techniques Blotting, Western Carcinoma, Non-Small-Cell Lung Mortality Prognosis Human ab: Rsf-1 (HBXAP) was recently reported to play roles in tumorigenesis and tumor progression. There have been many reports referred to Rsf-1 overexpression in various cancers and associated with the malignant behavior of cancer cells. However, the molecular mechanism of Rsf-1 in non-small cell lung cancer aggressiveness remains ambiguous. In the present study, we found that there was a significant association between Rsf-1 overexpression and poor overall survival (p = 0.028) in lung cancer. Furthermore, knockdown of Rsf-1 expression in H1299 and H460 cells with high endogenous Rsf-1 expression inhibited cell migration and invasion and downregulated MMP2 expression and nuclear levels of NF-κB. NF-κB inhibitor could also block the effect of Rsf-1 in regulation of MMP2 expression. Further experiments demonstrated that Rsf-1 depletion restrained NF-κB reporter luciferase activity and downregulated bcl-2 and p-IκB protein level. In conclusion, we demonstrated that Rsf-1 was overexpressed in lung cancer and associated with poor survival. Rsf-1 regulated cell invasion through MMP2 and NF-κB pathway. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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