Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods.
Purpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recogn...
| Publicado en: | International Journal of Endocrinology pp. 1 - 8 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
4/26/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122712309&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122712309 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16878337 8NCM jtl: International Journal of Endocrinology issn: 16878337 maglogo: N pubinfo: dt: 4/26/2017 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 122712309 10.1155/2017/8234502 122712309 ppf: 1 ppct: 7 formats: tig: atl: Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods. aug: au: Paprocka, Justyna Kijonka, Marek Boguszewicz, Łukasz Sokół, Maria affil: Department of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland sug: ab: Purpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recognized TSC. The parameters of the melatonin secretion models were interpreted and compared with those obtained for the patients with epilepsy (n=76) and the children from the control, nonepileptic group (n=36). To describe the diurnal melatonin secretion, mathematical model was constructed and nonlinear least squares method with the Levenberg-Marquardt optimization algorithm was applied to approximate its parameters. The dim light melatonin onset (DLMO) parameters were also estimated from the model. Results and Conclusions. Statistically significant differences were found between the TSC melatonin secretion profiles and the nonepileptic control group. The profiles for the epileptic and TSC groups were found to be similar. For the TSC group, though a small one, the variations in the MLT release amplitudes seem to be independent of the total number of seizures; however, the MLT release shift appears to depend on the number of seizures. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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