The functional connectivity in the motor loop of human basal ganglia.
Basal ganglia interact in a complex way which is still not completely understood. The model generally used to explain basal ganglia interactions is based on experimental data in animals, but its validation in humans has been hampered by methodological restrictions. The time-relationship (partial cor...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 2; pp. 417 - 430 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122726376&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122726376 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2017 vid: 11 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122726376 122726376 NLM26935555 122726376 10.1007/s11682-016-9512-y NLM26935555 122726376 ppf: 417 ppct: 13 formats: fmt: @attributes: type: P tig: atl: The functional connectivity in the motor loop of human basal ganglia. aug: au: Rodriguez-Sabate, Clara Sabate, Magdalena Llanos, Catalina Morales, Ingrid Sanchez, Alberto Rodriguez, Manuel affil: Department of Pharmacology and Physical Medicine, Faculty of Medicine , University of La Laguna , Tenerife Spain sug: subj: Basal Ganglia Physiology Psychomotor Performance Frontal Lobe Physiology Brain Mapping Methods Models, Biological Movement Physiology Male Nervous System Computer Simulation Aged Neural Pathways Physiology Adult Female Magnetic Resonance Imaging Methods Adolescence Young Adult Middle Age Human Aged: 65+ years Adult: 19-44 years Adolescent: 13-18 years Middle Aged: 45-64 years Male Female ab: Basal ganglia interact in a complex way which is still not completely understood. The model generally used to explain basal ganglia interactions is based on experimental data in animals, but its validation in humans has been hampered by methodological restrictions. The time-relationship (partial correlation) of the fluctuations of the blood-oxygen-level-dependent signals recorded in the main basal ganglia was used here (32 healthy volunteers; 18-72 years of age; 16 males and 16 females) to test whether the interaction of the main basal ganglia in humans follows the pattern of functional connectivity in animals. Data showed that most basal ganglia have a functional connectivity which is compatible with that of the established closed-loop model. The strength of the connectivity of some basal ganglia changed with finger motion, suggesting that the functional interactions between basal ganglia are quickly restructured by the motor tasks. The present study with the motor cortico-BG loop centers supports the circling dynamic of the basal ganglia model in humans, showing that motor tasks may change the functional connectivity of these centers. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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