The relationship between microvasculature in white matter hyperintensities and cognitive function.
White matter hyperintensities (WMHs) are associated with cognitive decline, but less is known about pathophysiology of cognitive decline in patients with WMHs. We investigated microvasculature and microstructure in WMHs using intravoxel incoherent motion (IVIM) and their associations with cognitive...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 2; pp. 503 - 512 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122726395&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122726395 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2017 vid: 11 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122726395 122726395 NLM26935550 122726395 10.1007/s11682-016-9531-8 NLM26935550 122726395 ppf: 503 ppct: 9 formats: fmt: @attributes: type: P tig: atl: The relationship between microvasculature in white matter hyperintensities and cognitive function. aug: au: Sun, Jianzhong Yu, Xinfeng Jiaerken, Yerfan Song, Ruirui Huang, Peiyu Wang, Chao Yuan, Lixia Mao, Yingying Guo, Yang Yu, Hualiang Zhang, Minming affil: Department of Radiology , The 2nd Affiliated Hospital of Zhejiang University, School of Medicine , Hangzhou China sug: subj: Brain Anatomy and Histology Brain Blood Supply Cognition Task Performance and Analysis Blood Vessels Anatomy and Histology Aging Magnetic Resonance Imaging Methods Aged Magnetic Resonance Angiography Methods Statistics Aged, 80 and Over Middle Age Sensitivity and Specificity Reproducibility of Results Male Female Adult Neuropsychological Tests Human Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: White matter hyperintensities (WMHs) are associated with cognitive decline, but less is known about pathophysiology of cognitive decline in patients with WMHs. We investigated microvasculature and microstructure in WMHs using intravoxel incoherent motion (IVIM) and their associations with cognitive function. Thirty-two subjects with WMHs were enrolled in our study. Fast diffusion coefficient (D*), perfusion fraction (f) and slow diffusion coefficient (D) from IVIM model were compared between regions of WMHs (periventricular WMHs, PWMHs and deep WMHs, DWMHs) and surrounding normal white matter. Multivariate linear model was used to determine the independent factors associated with cognitive function assessed by the Mini Mental State Examination (MMSE) and the standardized coefficient (β) of factors was estimated. D* was significantly lower (4.95 × 10-3 mm2/s versus 8.36 × 10-3 mm2/s in PWMHs and 5.04 × 10-3 mm2/s versus 8.67 × 10-3 mm2/s in DWMHs, both P < 0.001), and f (14.64 % versus 12.01 % in PWMHs and 14.26 % versus 11.31 % in DWMHs, both P < 0.001) and D (1.02 × 10-3 mm2/s versus 0.73 × 10-3 mm2/s in PWMHs and 0.86 × 10-3 mm2/s versus 0.70 × 10-3 mm2/s in DWMHs, both P < 0.001) were significantly higher in WMHs. Only f in PWMHs was independently associated with MMSE (β = 0.443, P = 0.016). The decreased D* and increased D in WMHs were similar to previous findings. The increased f in PWMHs relating with better cognition provides the pathophysiological basis in understanding cognitive decline in patients with WMHs. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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