"Small World" architecture in brain connectivity and hippocampal volume in Alzheimer's disease: a study via graph theory from EEG data.
Brain imaging plays an important role in the study of Alzheimer's disease (AD), where atrophy has been found to occur in the hippocampal formation during the very early disease stages and to progress in parallel with the disease's evolution. The aim of the present study was to evaluate a possible co...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 2; pp. 473 - 486 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122726398&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122726398 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2017 vid: 11 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122726398 122726398 NLM26960946 122726398 10.1007/s11682-016-9528-3 NLM26960946 122726398 ppf: 473 ppct: 13 formats: fmt: @attributes: type: P tig: atl: "Small World" architecture in brain connectivity and hippocampal volume in Alzheimer's disease: a study via graph theory from EEG data. aug: au: Vecchio, Fabrizio Miraglia, Francesca Piludu, Francesca Granata, Giuseppe Romanello, Roberto Caulo, Massimo Onofrj, Valeria Bramanti, Placido Colosimo, Cesare Rossini, Paolo Rossini, Paolo Maria affil: Brain Connectivity Laboratory, IRCCS San Raffaele Pisana , Via Val Cannuta, 247 00166 Rome Italy sug: subj: Models, Biological Hippocampus Physiopathology Alzheimer's Disease Physiopathology Brain Physiology Electroencephalography Methods Nervous System Physiopathology Brain Mapping Methods Hippocampus Pathology Nervous System Pathology Female Male Neural Pathways Physiopathology Computer Simulation Body Weights and Measures Alzheimer's Disease Pathology Aged Neural Pathways Pathology Human Neuropsychological Tests Aged: 65+ years Female Male ab: Brain imaging plays an important role in the study of Alzheimer's disease (AD), where atrophy has been found to occur in the hippocampal formation during the very early disease stages and to progress in parallel with the disease's evolution. The aim of the present study was to evaluate a possible correlation between "Small World" characteristics of the brain connectivity architecture-as extracted from EEG recordings-and hippocampal volume in AD patients. A dataset of 144 subjects, including 110 AD (MMSE 21.3) and 34 healthy Nold (MMSE 29.8) individuals, was evaluated. Weighted and undirected networks were built by the eLORETA solutions of the cortical sources' activities moving from EEG recordings. The evaluation of the hippocampal volume was carried out on a subgroup of 60 AD patients who received a high-resolution T1-weighted sequence and underwent processing for surface-based cortex reconstruction and volumetric segmentation using the Freesurfer image analysis software. Results showed that, quantitatively, more correlation was observed in the right hemisphere, but the same trend was seen in both hemispheres. Alpha band connectivity was negatively correlated, while slow (delta) and fast-frequency (beta, gamma) bands positively correlated with hippocampal volume. Namely, the larger the hippocampal volume, the lower the alpha and the higher the delta, beta, and gamma Small World characteristics of connectivity. Accordingly, the Small World connectivity pattern could represent a functional counterpart of structural hippocampal atrophying and related-network disconnection. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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