Altered modular organization of intrinsic brain functional networks in patients with Parkinson's disease.
Although previous studies reported altered topology of brain functional networks in patients with Parkinson's disease (PD), the modular organization of brain functional networks in PD patients remains largely unknown. Using the resting-state functional MRI (R-fMRI) and graph theory, we examined the...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 2; pp. 430 - 444 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122726402&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122726402 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2017 vid: 11 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122726402 122726402 NLM26860909 122726402 10.1007/s11682-016-9524-7 NLM26860909 122726402 ppf: 430 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Altered modular organization of intrinsic brain functional networks in patients with Parkinson's disease. aug: au: Ma, Qing Huang, Biao Wang, Jinhui Seger, Carol Yang, Wanqun Li, Changhong Wang, Junjing Feng, Jieying Weng, Ling Jiang, Wenjie Huang, Ruiwang affil: Center for the Study of Applied Psychology, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology , South China Normal University , Guangzhou 510631 China sug: subj: Brain Mapping Methods Brain Physiopathology Models, Biological Adaptation, Physiological Nervous System Physiopathology Parkinson Disease Physiopathology Male Computer Simulation Female Magnetic Resonance Imaging Methods Middle Age Human Middle Aged: 45-64 years Male Female ab: Although previous studies reported altered topology of brain functional networks in patients with Parkinson's disease (PD), the modular organization of brain functional networks in PD patients remains largely unknown. Using the resting-state functional MRI (R-fMRI) and graph theory, we examined the modular organization of brain functional networks in 32 unmedicated patients with early-to-mid motor stage PD and 31 healthy controls. Compared to the controls, the PD patients tended to show decreased integrity and segregation, both within and between modules. This was inferred by significantly increased intra-modular characteristic path length (L p) within four modules: mPFC, SN, SMN, and FPN, decreased inter-modular functional connectivity (FC) between mPFC and SN, SMN, and VN, and decreased intra-modular clustering in the PD patients. Intra-modular characteristic path length within the mPFC showed significantly positive correlation with general cognitive ability in the PD group. Receiver operating characteristic (ROC) analysis revealed that FC between mPFC and SN had the highest significant accuracy in differentiating the patients from the controls. Our findings may provide new insight in understanding the pathological changes that underlie impairment in cognition and movement in Parkinson's disease. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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