Association between Helicobacter Pylori Infection and Alopecia Areata: A Study in Iranian Population.
BACKGROUND Alopecia areata is an immune mediated inflammatory hair loss, which occurs in all ethnic and age groups, and both sexes. However no significant etiology has been known for this disease. Helicobacter pylori (H. pylori), is an organism colonized in gastric mucosa. This bacterium has been as...
| Publicado en: | Middle East Journal of Digestive Diseases Vol. 9; no. 2; pp. 107 - 111 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
Apr2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122754312&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122754312 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085230 BG4K jtl: Middle East Journal of Digestive Diseases issn: 20085230 maglogo: N pubinfo: dt: Apr2017 vid: 9 iid: 2 pid: 70725 pub: Iranian Association of Gastroenterology & Hepatology artinfo: ui: 122754312 122754312 122754312 10.15171/mejdd.2017.59 122754312 ppf: 107 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Association between Helicobacter Pylori Infection and Alopecia Areata: A Study in Iranian Population. aug: au: Behrangi, Elham Mansouri, Parvin Agah, Shahram Daryani, Nasser Ebrahimi Mokhtare, Marjan Azizi, Zahra Ghamsari, Mona Ramezani Nasab, Masoumeh Rohani Azizian, Zahra affil: Associate Professor, Department of Dermatology and Laser Surgery, Clinical Research Center, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran sug: subj: Helicobacter Infections Risk Factors Alopecia Areata Physiopathology Alopecia Areata Epidemiology Helicobacter Infections Epidemiology Prospective Studies Urease Breath Tests Data Analysis Software P-Value Middle Age Young Adult Male Multivariate Analysis Iran Prevalence Middle Aged: 45-64 years Male ab: BACKGROUND Alopecia areata is an immune mediated inflammatory hair loss, which occurs in all ethnic and age groups, and both sexes. However no significant etiology has been known for this disease. Helicobacter pylori (H. pylori), is an organism colonized in gastric mucosa. This bacterium has been associated with certain extra-digestive dermatological conditions. The causal relationship between alopecia areata and H. pylori infection has been discussed in literature. Therefore, we conducted this study to evaluate the prevalence of H. pylori infection in patients with alopecia areata and assess the risk of this infection in patients with this disease in order to determine its potential roles in the physiopathology of this disease. METHODS Between 2014 and 2015, we prospectively studied 81 patients with alopecia areata and 81 healthy volunteers with similar age and sex. Patients without any history of H. pylori infection were included in the study and underwent urease breath test. All results were analyzed using SPSS software (version 21.0) and p value<0.05 was considered as statistically significant. RESULTS 81 patients and 81 controls with the mean age of 34.9±11.6 and 38.2±13.4 years were studied (p=0.097). 48 (59.3%) and 45 (55.6%) individuals were male, in cases and control groups respectively (p =0.634). The result of urea breath test (UBT) was positive in 43 (53.1%) patients in cases and 27 (33.3%) individuals in control group, which was significantly different (p =0.011). The risk of H. pylori infection in alopecia areata was 2.263 (95% CI: 1.199-4.273). CONCLUSION The results of our study showed significant difference between H. pylori infection in individuals with and without alopecia areata, which shows that H. pylori contamination may be effective in physiopathology of alopecia areata. Therefore these results should be tested in large multivariable cohorts and controlled trials to reach more accurate evidence in the future and to generalize this idea to larger population. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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