Investigation of volumetric apparent diffusion coefficient histogram analysis for assessing complete response and clinical outcomes following pre-operative chemoradiation treatment for rectal carcinoma.
Purpose: To investigate the relationship of pre-treatment volumetric apparent diffusion coefficient (ADC) histogram parameters with post-operative histopathologic treatment response and clinical outcomes following pre-operative chemoradiation treatment (CRT) in rectal cancer. Materials and methods:...
| Publicado en: | Abdominal Radiology Vol. 42; no. 5; pp. 1310 - 1319 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122762440&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122762440 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: May2017 vid: 42 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122762440 10.1007/s00261-016-1010-6 122762440 ppf: 1310 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Investigation of volumetric apparent diffusion coefficient histogram analysis for assessing complete response and clinical outcomes following pre-operative chemoradiation treatment for rectal carcinoma. aug: au: Chidambaram, Vijay Brierley, James Cummings, Bernard Bhayana, Rajesh Menezes, Ravi Kennedy, Erin Kirsch, Richard Jhaveri, Kartik affil: Royal Liverpool and Broadgreen University Hospitals, NHS Trust , Prescot Street Liverpool L7 8XP UK sug: ab: Purpose: To investigate the relationship of pre-treatment volumetric apparent diffusion coefficient (ADC) histogram parameters with post-operative histopathologic treatment response and clinical outcomes following pre-operative chemoradiation treatment (CRT) in rectal cancer. Materials and methods: In a Health Insurance Portability and Accountability Act compliant retrospective study, 78 rectal cancer patients treated with pre-operative CRT and rectal MRI were included. MR imaging analysis was performed using OncoTREAT (software tool). Multiple volumetric ADC histogram parameters (voxel distribution across ADC ranges, kurtosis, and skewness) were assessed. Correlation was made to post-operative pathological complete response, clinical, or radiological evidence of disease progression using the Mann-Whitney test. Results: Post CRT, 8 patients showed pathologic complete response and 13 patients showed distant disease progression. Pre-treatment mean ADC was 1.2 × 10 mm/s (range 0.3-1.99 × 10 mm/s). Mean kurtosis measured was 0.56 (range −1 to 6; SD 1.36). Mean skewness was 0.3 (range −1 to 2; SD 0.69). Skewness had significant correlation ( p value = 0.006) with disease progression. The mean rectal tumor volume was 24cc (range 1cc-134cc). Pre-treatment MRI tumor volume showed significant correlation ( p value = 0.013) with pathologic complete response. Mean ADC and percentage voxels distribution against ADC ranges had no significant correlation with treatment response or disease outcomes. Conclusion: Volumetric ADC histogram analysis of pre-CRT rectal cancer MRI appears promising for prediction of post-CRT complete response and disease progression. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|