Clinical and Functional Lung Parameters Associated With Frequent Exacerbator Phenotype in Subjects With Severe COPD.
BACKGROUND: COPD is currently recognized as a syndrome associated with a high prevalence of comorbidities and various phenotypes. Exacerbations are very important events in the clinical history of COPD because they drive the decline in lung function. In the present study, we aim to identify whether...
| Publicado en: | Respiratory Care Vol. 62; no. 5; pp. 572 - 579 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
May2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122802976&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122802976 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: May2017 vid: 62 iid: 5 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 122802976 122802976 122802976 10.4187/respcare.05278 122802976 ppf: 572 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Clinical and Functional Lung Parameters Associated With Frequent Exacerbator Phenotype in Subjects With Severe COPD. aug: au: Capozzolo, Alberto Carratù, Pierluigi Dragonieri, Silvano Falcone, Vito Antonio Quaranta, Vitaliano Nicola Liotino, Vito D'Alba, Giuseppina Castellana, Giorgio Resta, Onofrio affil: Institute of Respiratory Disease, Department of Cardiac, Thoracic, and Vascular Science, University of Medicine, Bari, Italy sug: subj: Pulmonary Disease, Chronic Obstructive Complications Lung Disease Exacerbation Phenotype Human Descriptive Statistics Cross Sectional Studies Case Control Studies Pulmonary Disease, Chronic Obstructive Classification Inspiration, Respiratory Scales Lung Volume Measurements Severity of Illness Italy Respiratory Function Tests Spirometry Total Lung Capacity Vital Capacity Forced Expiratory Volume P-Value T-Tests Mann-Whitney U Test Fisher's Exact Test Chi Square Test Multiple Logistic Regression Spearman's Rank Correlation Coefficient Male Female Aged Middle Age Odds Ratio Confidence Intervals Pulmonary Disease, Chronic Obstructive Drug Therapy Aged: 65+ years Middle Aged: 45-64 years Male Female ab: BACKGROUND: COPD is currently recognized as a syndrome associated with a high prevalence of comorbidities and various phenotypes. Exacerbations are very important events in the clinical history of COPD because they drive the decline in lung function. In the present study, we aim to identify whether there are any clinical and functional specific features of frequent exacerbators in a population of patients with severe COPD. METHODS: We conducted a cross-sectional, case control study. All subjects had Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 3 or 4 COPD (FEV1 < 50% predicted). Frequent exacerbators (n = 183) reported ≥2 exacerbations or ≥1 determining hospitalization during the previous 12 months, and infrequent exacerbators (n = 162) reported <2 exacerbations over the last 12 months without hospitalization. Multivariate logistic regression was performed to determine the clinical and functional factors significantly associated with frequent exacerbator status. RESULTS: Frequent exacerbators had a significantly lower inspiratory capacity percentage predicted. The Motley index (residual volume/total lung capacity percentage) was significantly increased in frequent exacerbators. Infrequent exacerbators had lower Modified Medical Research Council dyspnea scale and BODE index than frequent exacerbators. In the multivariate model, a reduced inspiratory capacity percentage predicted and an increase of residual volume/total lung capacity percentage, BODE index and Modified Medical Research Council dyspnea scale were associated with the frequent exacerbation phenotype. CONCLUSIONS: Static hyperinflation and respiratory disability, measured by Motley index and Modified Medical Research Council dyspnea scale, respectively, in the same way as the multidimensional BODE index staging system, were independently associated with frequent exacerbation status in subjects with severe COPD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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